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Metabolism in Cancer

  • Book
  • © 2016

Overview

Editors:
  1. Thorsten Cramer

    1. RWTH University Hospital, Molecular Tumor Biology, Pauwelsstrasse 30, 52074 , Aachen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Clemens A. Schmitt

    1. Dept. of Hematology and Oncology, Charité, Berlin, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers a variety of important aspects of cancer-associated metabolism
  • Presents and discusses the latest discoveries in the field
  • Written by internationally respected experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 207)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

    • Charlene Brault, Almut Schulze
    Pages 1-22

  3. Lactate—An Integrative Mirror of Cancer Metabolism

    • Stefan Walenta, Nadine F. Voelxen, Wolfgang Mueller-Klieser
    Pages 23-37

  4. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer

    • Evan C. Lien, Costas A. Lyssiotis, Lewis C. Cantley
    Pages 39-72

  5. MYC, Metabolic Synthetic Lethality, and Cancer

    • Annie L. Hsieh, Chi V. Dang
    Pages 73-91

  6. The Role of pH Regulation in Cancer Progression

    • Alan McIntyre, Adrian L. Harris
    Pages 93-134

  7. Metabolic Features of Cancer Treatment Resistance

    • Andrea Viale, Giulio F. Draetta
    Pages 135-156

  8. Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome

    • Jan Budczies, Carsten Denkert
    Pages 157-175

  9. Imaging of Tumor Metabolism Using Positron Emission Tomography (PET)

    • Ivayla Apostolova, Florian Wedel, Winfried Brenner
    Pages 177-205

  10. Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA

    • Christin Zasada, Stefan Kempa
    Pages 207-220

  11. Mathematical Modeling of Cellular Metabolism

    • Nikolaus Berndt, Hermann-Georg Holzhütter
    Pages 221-232

  12. Ketogenic Diet and Cancer—a Perspective

    • Christopher Smyl
    Pages 233-240

  13. Fasting and Caloric Restriction in Cancer Prevention and Treatment

    • Sebastian Brandhorst, Valter D. Longo
    Pages 241-266
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Keywords

About this book

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications.Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Editors and Affiliations

  • RWTH University Hospital, Molecular Tumor Biology, Pauwelsstrasse 30, 52074 , Aachen, Germany

    Thorsten Cramer

  • Dept. of Hematology and Oncology, Charité, Berlin, Germany

    Clemens A. Schmitt

Bibliographic Information

  • Book Title: Metabolism in Cancer

  • Editors: Thorsten Cramer, Clemens A. Schmitt

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-319-42118-6

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-42116-2Published: 13 September 2016

  • Softcover ISBN: 978-3-319-82501-4Published: 14 June 2018

  • eBook ISBN: 978-3-319-42118-6Published: 24 August 2016

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: IX, 266

  • Number of Illustrations: 6 b/w illustrations, 25 illustrations in colour

  • Topics: Oncology, Immunology, Biochemistry, general, Cell Biology

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