Overview
- A comprehensive investigation into the regulation of Ca2+-ATPases, F-type ATPases, and V-type ATPases
- Explores the specific inhibitors and molecular probes for membrane ATPases to improve the therapy of various diseases
- An informative resource to improve diverse ATPase therapeutic approaches of life threatening diseases
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 14)
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Table of contents (29 chapters)
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Front Matter
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Plasma Membrane ATPases
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Front Matter
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Sarco(endo)plasmic Reticulum ATPases
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Front Matter
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Keywords
About this book
The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase
and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby  bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.Editors and Affiliations
Bibliographic Information
Book Title: Regulation of Ca2+-ATPases,V-ATPases and F-ATPases
Editors: Sajal Chakraborti, Naranjan S Dhalla
Series Title: Advances in Biochemistry in Health and Disease
DOI: https://doi.org/10.1007/978-3-319-24780-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-24778-6Published: 16 December 2015
Softcover ISBN: 978-3-319-79677-2Published: 27 March 2019
eBook ISBN: 978-3-319-24780-9Published: 10 December 2015
Series ISSN: 2512-2142
Series E-ISSN: 2512-2150
Edition Number: 1
Number of Pages: XIII, 586
Number of Illustrations: 75 b/w illustrations, 26 illustrations in colour
Topics: Protein Structure, Membrane Biology, Protein Science, Atomic/Molecular Structure and Spectra, Molecular Medicine