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Recurrent Implantation Failure

Etiologies and Clinical Management

  • Book
  • © 2018

Overview

Editors:
  1. Jason M. Franasiak

    1. Reproductive Medicine Associates of NJ, Thomas Jefferson University, Basking Ridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard T. Scott Jr.

    1. Reproductive Medicine Associates of NJ, Thomas Jefferson University, Basking Ridge, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses the wide range of causes and conditions resulting in recurrent implantation failure (RIF) and its current clinical management

  • Examines genetic, immune and environmental factors as well as abnormalities of the anatomy, hematologic and endocrine systems leading to RIF

  • Ideal for reproductive endocrinologists and infertility specialists working with these challenging patients

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Signaling Between Embryo and Endometrium: Normal Implantation

    • Chelsea Fox, Bruce A. Lessey
    Pages 1-19

  3. Embryo and Endometrial Synchrony in Implantation Failure

    • Jason M. Franasiak, Richard T. Scott
    Pages 21-31

  4. Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?

    • Sorena Keihani, Jeremy B. Myers, James M. Hotaling
    Pages 33-58

  5. Embryonic Factors Associated with Recurrent Implantation Failure

    • Daniel J. Kaser, Catherine Racowsky
    Pages 59-75

  6. The Genetics of Pregnancy Failure

    • Eric J. Forman, Nathan Treff, Rebekah S. Zimmerman
    Pages 77-91

  7. Immune Factors in Recurrent Implantation Failure

    • Diana Alecsandru, Juan A. Garcia-Velasco
    Pages 93-102

  8. Stress and Implantation Failure

    • Jeffrey L. Deaton, Bonnie Patel, Erika Johnston-MacAnanny, Jie Yu, Shannon D. Whirledge, Alexandra Wilson et al.
    Pages 103-124

  9. Hematologic Disease in Implantation Failure

    • Shelby A. Neal, Jason M. Franasiak, Richard T. Scott
    Pages 125-134

  10. Endocrine Causes of Implantation Failure

    • Scott Morin, Baris Ata, Emre Seli
    Pages 135-152

  11. Anatomic Abnormalities and Recurrent Implantation Failure

    • Jeffrey M. Goldberg, Julian Gingold, Natalia Llarena
    Pages 153-174

  12. Microbiome in Embryonic Implantation and Implantation Failure

    • Jason M. Franasiak, Inmaculada Moreno, Carlos Simon
    Pages 175-195

  13. Psychosocial Implications of Recurrent Implantation Failure

    • Andrea Mechanick Braverman, Keren Sofer
    Pages 197-210

  14. Back Matter

    Pages 211-215
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Keywords

About this book

This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. 



Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists. 




Editors and Affiliations

  • Reproductive Medicine Associates of NJ, Thomas Jefferson University, Basking Ridge, USA

    Jason M. Franasiak, Richard T. Scott Jr.

About the editors

Jason M. Franasiak, MD, TS (ABB), Assistant Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA

Richard T. Scott, MD, HCLD/ALD (ABB), Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA

Bibliographic Information

  • Book Title: Recurrent Implantation Failure

  • Book Subtitle: Etiologies and Clinical Management

  • Editors: Jason M. Franasiak, Richard T. Scott Jr.

  • DOI: https://doi.org/10.1007/978-3-319-71967-2

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-71966-5Published: 13 April 2018

  • Softcover ISBN: 978-3-030-10137-4Published: 25 December 2018

  • eBook ISBN: 978-3-319-71967-2Published: 03 April 2018

  • Edition Number: 1

  • Number of Pages: XIII, 215

  • Number of Illustrations: 3 b/w illustrations, 29 illustrations in colour

  • Topics: Reproductive Medicine, Endocrinology

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