Biochemical Basis and Therapeutic Implications of Angiogenesis

1. Front Matter

   Pages i-ix

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2. Molecular Mechanisms in Angiogenesis

   1. Front Matter

      Pages 1-1

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   2. Endothelial Growth Factor Receptors in Angiogenesis

      • David J. Bruce, Peng H. Tan

      Pages 3-22

   3. The Role of Integrins in Angiogenesis

      • Ghazaleh Tabatabai

      Pages 23-36

   4. Toll-Like Receptors in Angiogenesis

      • Karsten Grote, Jutta Schuett, Harald Schuett, Bernhard Schieffer

      Pages 37-58

   5. Vascular Stem Cells in Regulation of Angiogenesis

      • Jingwei Lu, Vincent J. Pompili, Hiranmoy Das

      Pages 59-74

   6. Role of Transforming Growth Factor Beta Family in Angiogenesis

      • Alicia Viloria-Petit, Amy Richard, Sonja Zours, Mai Jarad, Brenda L. Coomber

      Pages 75-103

   7. Angiogenesis-Based Strategy by Hepatocyte Growth Factor for the Treatment of Ischemic Organ Diseases: From Biology to Clinical Trials

      • Shinya Mizuno

      Pages 105-131

   8. Functions of MicroRNAs in Angiogenesis

      • Xiao Li, Yuqiao Chang, Zufeng Ding, Zhikun Guo, Jawahar L. Mehta, Xianwei Wang

      Pages 133-155

   9. Mast Cells in Angiogenesis: The Role of Angiogenic Cytokines

      • Domenico Ribatti

      Pages 157-167

3. Therapeutic Implications of Angiogenesis in Cancer

   1. Front Matter

      Pages 169-169

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   2. Therapeutic Implications of Angiogenesis in Cancer

      • Issam Makhoul, Shebli Atrash, Konstantinos Arnaoutakis, Mazin Safar, Angela Pennisi, Laura Huffman et al.

      Pages 171-216

   3. The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior

      • Ramon Andrade De Mello, Michael Luis, António Araújo, Rui Manuel Reis, Venceslau Hespanhol

      Pages 217-239

   4. Angiogenesis and Prostate Cancer: Friends or Foes

      • Sanja Stifter, Federica Patrinicola, Gianluigi Taverna, Fabio Grizzi

      Pages 241-256

4. Therapeutic Implications of Angiogenesis in Eye Disorders

   1. Front Matter

      Pages 257-257

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   2. Angiogenesis-Based Therapies for Eye Diseases

      • Rajkumar Patil, Chee Wai Wong, Fabio Michelet, Kelvin Teo, Daniel Ting, Andrew Tsai et al.

      Pages 259-297

   3. Anti-angiogenesis Therapy in Diabetic Retinopathy

      • Michael W. Stewart

      Pages 299-323

5. Therapeutic Implications of Angiogenesis in Cardiovascular Disorders and Peripheral Vascular Disease

   1. Front Matter

      Pages 325-325

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   2. Therapeutic Angiogenesis, Cell Therapy and Peripheral Vascular Disease

      • Brian H. Annex

      Pages 327-342

   3. Cell-Based Therapy in Ischemic Heart Disease

      • Adnan Khan, Akshay Menon, Jörn Tongers

      Pages 343-359

This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis.

This book also:

Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr

ins in angiogenesis, angiogenesis and exercise physiology, and more

Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure

Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease

• Angiogenesis
• Angiogenesis and Aging
• Angiogenesis Atherosclerosis Heart Disease
• Angiogenesis Brain
• Angiogenesis in Cancer
• Angiogenesis Neurology
• Angiogenesis Oncology
• Angiogenesis Opthalmology
• Angiogenesis Peripheral Vascular Disease
• Angiogenesis Physiology
• Angiogenesis Systemic Sclerosis
• Angiogenesis Wound Repair
• Atherosclerosis
• Diabetes Angiogenesis Metabolic Disorders
• Ischemic Heart Disease
• Receptors

• Divison of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, USA

  Jawahar L. Mehta

• Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA

  Pankaj Mathur

• Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

  Naranjan S. Dhalla

Professor Jawahar L. Mehta is the Stebbins Chair and Professor of Medicine at the College of Medicine, University of Arkansas for Medical Sciences (UAMS).

Dr. Naranjan S. Dhalla is the Principal Investigator, Experimental Cardiology at the Institute of Cardiovascular Sciences and is Distinguished Professor in the Faculty of Medicine, Professor of Physiology at the University of Manitoba and Senior Fellow at the Centre for the Advancement of Medicine.

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