Abdominal Sepsis

1. Front Matter

   Pages i-xi

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2. Classification and Principals of Treatment

   • Amelia Simpson, Leslie Kobayashi, Raul Coimbra

   Pages 1-14

3. Inflammatory Mediators in Intra-abdominal Sepsis

   • Andrew W. Kirkpatrick, Jimmy Xiao, Craig N. Jenne, Derek J. Roberts

   Pages 15-28

4. Intra-abdominal Sepsis and Imaging Considerations

   • Asanthi M. Ratnasekera, Paula Ferrada

   Pages 29-36

5. High-Risk Patients and Prognostic Factors for Abdominal Sepsis

   • Bruno M. Pereira, Gustavo P. Fraga

   Pages 37-45

6. Acute Appendicitis: What Is the Best Strategy to Treat Acute Appendicitis (Both Complicated and Uncomplicated)?

   • Matteo Mandrioli, Massimo Sartelli, Arianna Birindelli, Edoardo Segalini, Fausto Catena, Federico Coccolini et al.

   Pages 47-50

7. Acute Cholecystitis

   • Paola Fugazzola, Federico Coccolini, Giulia Montori, Cecilia Merli, Michele Pisano, Luca Ansaloni

   Pages 51-64

8. Acute Cholangitis

   • Zhongkai Wang, Saleem Ahmed, Vishal G. Shelat

   Pages 65-81

9. Pyogenic Liver Abscess

   • Yeo Danson, Tan Ming Yuan, Vishal G. Shelat

   Pages 83-93

10. Gastroduodenal Perforations

    • Kjetil Søreide

    Pages 95-103

11. Small Bowel Perforations

    • Sanjy Marwah

    Pages 105-162

12. Acute Colonic Diverticulitis

    • Jan Ulrych

    Pages 163-177

13. Postoperative Peritonitis: Etiology, Diagnosis, and Treatment

    • Torsten Herzog, Waldemar Uhl

    Pages 179-200

14. Damage Control Surgery in Managing Abdominal Sepsis (Fausto Catena, Italy)

    • Fausto Catena, Gennaro Perrone

    Pages 201-209

15. Ongoing Peritonitis

    • Andreas Hecker, Birgit Hecker, Christoph Lichtenstern, Matthias Hecker, Jens G. Riedel, Markus A. Weigand et al.

    Pages 211-224

16. Evolving Treatment Strategies for Severe Clostridium difficile Colitis: Defining the Therapeutic Window

    • Peter K. Kim, Peng Zhao, Sheldon Teperman

    Pages 225-239

17. Complicated Intra-abdominal Infections: Principles of Antimicrobial Therapy

    • Matteo Bassetti, Elda Righi, Massimo Sartelli

    Pages 241-247

18. Antimicrobial Armamentarium

    • Sean M. Stainton, David P. Nicolau

    Pages 249-263

19. Antimicrobial Resistance in Intra-abdominal Infections

    • Garyphallia Poulakou, Georgios Siakallis, Sotirios Tsiodras

    Pages 265-286

20. The Role of Candida in Abdominal Sepsis

    • Philippe Montravers, Aurélie Snauwaert, Claire Geneve, Mouna Ben Rehouma

    Pages 287-300

This book examines in detail the topic of sepsis, with a focus on intra-abdominal sepsis. Particular attention is devoted to source control in the management of the infection, antimicrobial therapy and sepsis support, which represent the cornerstones of treating patients with this problem. The importance of a multidisciplinary approach is highlighted not only by the instructive and informative sections on the acute manifestations of appendicitis, cholecystitis, and cholangitis, perforations and diverticulitis, Clostridium difficile infection and the role of candida in abdominal sepsis, but also by an extensive discussion of issues including antimicrobial resistance, damage control surgery, principles of antimicrobial therapy, hemodynamic support, adjunctive therapies, and thromboprophylaxis.

Abdominal sepsis is the host’s systemic inflammatory response to intra-abdominal infections. It is associated with significant morbidity and mortality rates, and represents the second mostcommon cause of sepsis-related mortality at intensive care units. Gathering contributions by authoritative experts from all around the world, this book will allow acute care surgeons, abdominal surgeons, intensive care clinicians, and students to broaden their understanding of intra-abdominal sepsis in daily clinical practice.

• acute appendicitis
• Intra-abdominal infections
• Peritonitis
• Antimicrobial resistance
• Resuscitation
• acute cholecystitis
• acute cholangitis
• gastroduodenal perforations
• small bowel perforations
• Acute diverticulitis
• Clostridium difficile infection
• candida in abdominal sepsis
• abdominal compartment syndrome
• abdominal surgery
• Trauma Surgery
• infectious diseases

• Department of Surgery, Macerata Hospital, Macerata, Italy

  Massimo Sartelli

• University of Udine, Infectious Diseases Division , Udine, Italy

  Matteo Bassetti

• St James's University Hospital, Trinity Centre for Health Sciences , Dublin, Ireland

  Ignacio Martin-Loeches

Dr Massimo Sartelli is Consultant Surgeon at the Department of Surgery, Macerata Hospital, Italy. He is author and co-author of 8 manuals of general-emergency surgery. In the last years he has devoted his updating to the study of surgical sepsis. He is deputy editor of the "World Journal of Emergency Surgery" and member of the Board of Directors of the "World Society of Emergency Surgery" (WSES).  In last years he coordinated WSES guidelines for management of intra-abdominal infections and soft tissue infections. He designed and coordinated three prospective studies describing the epidemiological and treatment profiles of patients with cIAIs worldwide.

Matteo Bassetti is Head of the Infectious Diseases Division of the Santa Maria Misericordia University Hospital, Udine, Italy. He is also Associate Professor of Infectious Diseases of the University of Udine. Dr Bassetti studied at the University of Genoa and continued his medical education at the Yale University School ofMedicine, New Haven, USA, with an Infectious Diseases fellowship. He also completed a PhD in Solid Organ Transplantation and Infectious Diseases at the University of Genoa. He is the secretary of the Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC) and chair of the Critically Ill Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Dr Bassetti is also co-chair of the Intra-abdominal Infections Study Group and  secretary of the Bone, Skin and Soft Tissue Infections of the International Society of Chemotherapy (ISC).

Ignacio Martin-Loeches, PhD, FJFICMI is a full time Consultant in Intensive Care Medicine and Senior Clinical Lecturer & Research Director of the Multidisciplinary Intensive Care Research Organization (MICRO) at Trinity College, Dublin. Currently Vice-Chair of Intensive Care Medicine at St James’s University Hospital, Dublin. He has served as executive member for the European Diploma in Intensive Care (EDIC) and as Deputy for the Sepsis and Infection Section at the European Society of Intensive Care Medicine (ESICM). He is the Chair of the Severe Sepsis and Septic Shock Working Group “4SWG” and executive member of the research-working group of the Surviving Sepsis Campaign (SSC). He is the currently member of the Clinical Trials of Health Research Board in Ireland and the President of the Spanish Research Society of Ireland[(under the Embassy of Spain in Ireland and The Spanish Foundation for Science and Technology (FECYT)]. He is principal Investigator of European Regional Development Funds (ERDF) grant and the European Network for ICU-related respiratory infections (ENIRRIs) under the European Respiratory Society (ERS). He has published several manuscripts in high impact factor journal and serves as section Editor at the Intensive Care Medicine (ICM) journal. 

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