Overview
- Editors:
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Susan Y. Smith
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Montreal, Canada
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Aurore Varela
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Charles River Preclinical Services, Senneville, Canada
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Rana Samadfam
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Charles River Preclinical Services, Senneville, Canada
- Comparative bone biology of animal species commonly used in toxicology studies with humans
- Special considerations highlighted for Juvenile toxicology
- Collection of chapters on bone interactions with other organ systems
- Includes supplementary material: sn.pub/extras
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Table of contents (15 chapters)
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Bone Toxicology in Preclinical Drug Testing
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- Susan Y. Smith, Nancy Doyle, Melanie Felx
Pages 3-26
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- Jürg Andreas Gasser, Michaela Kneissel
Pages 27-94
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Methods in Bone Research
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Front Matter
Pages 173-173
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- Susan Y. Smith, Rana Samadfam
Pages 175-201
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- Angela S. P. Lin, Gabrielle Boyd, Aurore Varela, Robert E. Guldberg
Pages 229-252
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- Reinhold G. Erben, Jacquelin Jolette, Luc Chouinard, Rogely Boyce
Pages 253-278
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Bone as an Endocrine Organ
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Front Matter
Pages 279-279
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- Chenglin Mo, Zhiying Wang, Lynda Bonewald, Marco Brotto
Pages 281-316
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- Tony Yuen, Li Sun, Wahid Abu-Amer, Peng Liu, Terry F. Davies, Harry C. Blair et al.
Pages 317-334
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- Olena V. Andrukhova, Reinhold G. Erben
Pages 335-362
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- Rishikesh N. Kulkarni, Paul A. Baldock
Pages 399-416
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- Fraser L. Collins, Soon Mi Kim, Laura R. McCabe, Connie M. Weaver
Pages 417-443
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Back Matter
Pages 465-474
About this book
The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide thebackground and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
About the editors
Susan Y. Smith is a consultant who specializes in nonclinical muscoloskeletal research. She provides guidance for the conduct of pharmacology, efficacy or safety studies, or help with data interpretation to unravel the mysteries of skeletal evaluations. She received a Master of Science in Pharmacology at McGill University and later joined Charles River Laboratories for almost 18 years and where she became Senior Scientific Director of Musculoskeletal Research. She has over 30 years of experience in preclinical safety assessments and toxicology and over 20 years of expertise in bone research.
