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Alternate Fractionation in Radiotherapy

Paradigm Change

  • Book
  • © 2018

Overview

Editors:
  1. Mark Trombetta

    1. Allegheny General Hospital Allegheny Health Network Cancer Institute, Drexel University College of Medicine, Pittsburgh, USA

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  2. Jean-Philippe Pignol

    1. Radiation Oncology Department, Erasmus University Medical Center, Rotterdam, The Netherlands

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  3. Paolo Montemaggi

    1. Allegheny Health Network, Temple University School of Medicine, Pittsburgh, USA

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  4. Luther W. Brady

    1. Hylda Cohn/American Cancer Society, Drexel University College of Medicine, Philadelphia, USA

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  • Describes alternate fractionation strategies using an evidence-based approach
  • Enhances patient care through precise dosing and targeting
  • Delivers reductions in regimen toxicity, treatment time, and cost
  • Written by leading international experts

Part of the book series: Medical Radiology (MEDRAD)

Part of the book sub series: Radiation Oncology (Med Radiol Radiat Oncol)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Introduction

    • Theodore E. Yaeger, Paolo Montemaggi, Mark Trombetta, Jean-Philippe Pignol, Luther Brady
    Pages 1-4

  3. The Radiobiological Aspects of Altered Fractionation

    • Alan E. Nahum, Richard P. Hill
    Pages 5-19

  4. Technological Advance Enabling Alternate Fractionation

    • Olivier Gayou
    Pages 21-30

  5. Workflow and Quality Assurance in Altered Fractionation

    • Geoffrey S. Ibbott
    Pages 31-39

  6. The Future of Altered Fractionation

    • Brian J. Gebhardt, Zachary D. Horne, Sushil Beriwal
    Pages 41-63

  7. Brachytherapy: The Original Altered Fractionation

    • Mark Trombetta, Janusz Skowronek
    Pages 65-73

  8. Disease Site Specific Topics

    1. Front Matter

      Pages 75-75
      Download chapter PDF

    2. Altered Fractionation in Radiotherapy of CNS Tumors

      • John C. Flickinger
      Pages 77-89

    3. Head and Neck Cancer

      • Olgun Elicin, E. Mahmut Ozsahin
      Pages 91-126

    4. Whole-Breast Hypofractionated Radiotherapy

      • Fernand Missohou, Mark Trombetta, Jean-Philippe Pignol
      Pages 127-139

    5. Accelerated Partial Breast Irradiation

      • Jean-Philippe Pignol, Nienke Hoekstra, Fernand Missohou, Mark Trombetta
      Pages 141-155

    6. Lung Cancer

      • Mauro Loi, J.J. Nuyttens
      Pages 157-172

    7. Alternate Fractionation for Hepatic Tumors

      • Alejandra Méndez Romero, Thomas B. Brunner, Alexander V. Kirichenko, Wolfgang A. Tomé, Yun Liang, Nathan Ogden et al.
      Pages 173-201

    8. Stereotactic Body Radiotherapy with Functional Treatment Planning in Hepatocellular Carcinoma

      • Alexander Kirichenko, Eugene J. Koay, Shaakir Hasan, Christopher Crane
      Pages 203-210

    9. Gastrointestinal Cancer: Pancreas

      • Linda Chen, Lauren M. Rosati, Joseph M. Herman
      Pages 211-227

    10. Hypofractionation in Patients with Rectal Cancer

      • Te Vuong, Slobodan Devic, Krzysztof Bujko
      Pages 229-239

    11. Hypofractionated Radiotherapy in Genitourinary Cancer: Better with Less

      • Ruud C. Wortel, Luca Incrocci
      Pages 241-256

    12. Fractionation Regimens for Gynecologic Malignancies

      • Joanne Jang, Patrizia Guerrieri, Akila N. Viswanathan
      Pages 257-272

    13. Skin: The Case for Altered Fractionation in the Treatment of Both Malignant and Benign Conditions

      • James Fontanesi, Brian Kopitzki, Richard Zekman
      Pages 273-305
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Keywords

About this book

This book, written by leading international experts, describes alternate fractionation strategies in which technology-driven precise targeting and dosing allow for improved conformance and decreased volumes, with concordant lessening of toxicity, reduction in treatment time, and lower overall health care expense. The aim is to provide the advanced clinician with an up-to-date evidence-based reference that will assist in the delivery of enhanced patient care in daily practice.

Traditional multi-week fractionation schedules were established at a time when the inclusion of relatively large amounts of normal tissue was unavoidable owing to the lack of accurate target localization during treatment. Such schedules are time and resource consuming, difficult for patients, and expensive. Nevertheless, acceptance of alternate fractionation strategies has been slow in some countries. The paradigm is, however, changing as evidence accumulates to demonstrate improved local control, equivalence of tolerance, or both. In documenting these alternate strategies, this book will be of value for radiation oncologists, medical physicists, and oncologists worldwide.

Reviews

“This book has a singular focus on the concept of alternate fractionation for radiation therapy. … The book will be of significant interest to radiation oncologists, particularly those treating a wide variety of tumors for which the number of alternate fractionation regimens has grown at a rapid pace in recent years. Students of radiobiology and physics and radiation oncology residents will also find the book of interest. The authors and contributors are credible authorities in their fields.” (Mark D. Hurwitz, Doody's Book Reviews, March, 2019)

Editors and Affiliations

  • Allegheny General Hospital Allegheny Health Network Cancer Institute, Drexel University College of Medicine, Pittsburgh, USA

    Mark Trombetta

  • Radiation Oncology Department, Erasmus University Medical Center, Rotterdam, The Netherlands

    Jean-Philippe Pignol

  • Allegheny Health Network, Temple University School of Medicine, Pittsburgh, USA

    Paolo Montemaggi

  • Hylda Cohn/American Cancer Society, Drexel University College of Medicine, Philadelphia, USA

    Luther W. Brady

Bibliographic Information

  • Book Title: Alternate Fractionation in Radiotherapy

  • Book Subtitle: Paradigm Change

  • Editors: Mark Trombetta, Jean-Philippe Pignol, Paolo Montemaggi, Luther W. Brady

  • Series Title: Medical Radiology

  • DOI: https://doi.org/10.1007/978-3-319-51198-6

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-51197-9Published: 09 October 2018

  • Softcover ISBN: 978-3-030-09596-3Published: 08 January 2019

  • eBook ISBN: 978-3-319-51198-6Published: 25 September 2018

  • Series ISSN: 0942-5373

  • Series E-ISSN: 2197-4187

  • Edition Number: 1

  • Number of Pages: XII, 413

  • Number of Illustrations: 65 b/w illustrations, 35 illustrations in colour

  • Topics: Radiotherapy, Oncology

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