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The Blood Brain Barrier and Inflammation

  • Book
  • © 2017

Overview

Editors:
  1. Ruth Lyck

    1. Theodor Kocher Institute, University of Bern, Bern, Switzerland

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  2. Gaby Enzmann

    1. Theodor Kocher Institute, University of Bern, Bern, Switzerland

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  • Provides a comprehensive overview on the role of the BBB during CNS inflammation
  • Covers inflammatory diseases, like autoimmune and viral induced CNS inflammation, cerebral malaria, multiple sclerosis, bacterial meningitis, and others
  • Presents methods to study neuro-inflammation, employing BBB animal models and imaging techniques

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
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  2. General Introduction to Barrier Mechanisms in the Central Nervous System

    • Norman R. Saunders, Katarzyna M. Dziegielewska, Kjeld MøllgÃ¥rd, Mark D. Habgood
    Pages 1-22

  3. Topological Aspects of the Blood–Brain and Blood–Cerebrospinal Fluid Barriers and Their Relevance in Inflammation

    • Friederike Pfeiffer, Andreas F. Mack, Hartwig Wolburg
    Pages 23-48

  4. The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions

    • Melanie-Jane Hannocks, Jula Huppert, Xueli Zhang, Eva Korpos, Lydia Sorokin
    Pages 49-60

  5. Pathophysiology of the Blood–Brain Barrier in Neuroinflammatory Diseases

    • Petra Majerova, Andrej Kovac
    Pages 61-79

  6. Leakage at Blood-Neural Barriers

    • Patric Turowski
    Pages 81-102

  7. Blood–Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology

    • Victoria Makrides, Elena Dolgodilina, Daniela Virgintino
    Pages 103-151

  8. microRNAs in Brain Endothelium and Inflammation

    • D. Roig-Carles, C. Cerutti, M. A. Lopez-Ramirez, D. Wu, David K. Male, H. E. de Vries et al.
    Pages 153-173

  9. Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases

    • Jessica L. Williams, Robyn S. Klein
    Pages 175-186

  10. Pathways Across the Blood-Brain Barrier

    • Michael Abadier, Ruth Lyck
    Pages 187-211

  11. Neuroinflammation in Bacterial Meningitis

    • Philipp Agyeman, Denis Grandgirard, Stephen L. Leib
    Pages 213-252

  12. Blood Vessels in the Brain: A Signaling Hub in Brain Tumor Inflammation

    • Sylvaine Guerit, Stefan Liebner
    Pages 253-277

  13. Back Matter

    Pages 279-286
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Keywords

About this book

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Editors and Affiliations

  • Theodor Kocher Institute, University of Bern, Bern, Switzerland

    Ruth Lyck, Gaby Enzmann

About the editors

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.

Bibliographic Information

  • Book Title: The Blood Brain Barrier and Inflammation

  • Editors: Ruth Lyck, Gaby Enzmann

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/978-3-319-45514-3

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-45512-9Published: 10 April 2017

  • Softcover ISBN: 978-3-319-83308-8Published: 21 July 2018

  • eBook ISBN: 978-3-319-45514-3Published: 29 March 2017

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: VI, 286

  • Number of Illustrations: 8 b/w illustrations, 24 illustrations in colour

  • Topics: Immunology, Neurosciences, Membrane Biology, Infectious Diseases, Cytokines and Growth Factors

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