HPV Infection in Head and Neck Cancer

1. Front Matter

   Pages i-vi

   PDF

2. Epidemiology and Molecular Biology of HPV Positive HNSCC

   1. Front Matter

      Pages 1-1

      PDF

   2. HPV in Head and Neck Cancer—30 Years of History

      • Stina Syrjänen, Jaana Rautava, Kari Syrjänen

      Pages 3-25

   3. Epidemiology of HPV-Positive Tumors in Europe and in the World

      • Xavier Castellsagué, Marisa Mena, Laia Alemany

      Pages 27-35

   4. Molecular Patterns and Biology of HPV-Associated HNSCC

      • Ruud H. Brakenhoff, Steffen Wagner, Jens P. Klussmann

      Pages 37-56

   5. HPV Integration in Head and Neck Squamous Cell Carcinomas: Cause and Consequence

      • Ernst Jan M. Speel

      Pages 57-72

   6. Risk Factors for Oral Infection with Human Papillomavirus

      • Pawel Golusinski

      Pages 73-85

3. HPV Testing

   1. Front Matter

      Pages 87-87

      PDF

   2. HPV-Related Head and Neck Squamous Cell Carcinomas

      • Andrzej Marszałek, Łukasz Szylberg

      Pages 89-100

   3. HPV Testing of Head and Neck Cancer in Clinical Practice

      • Max Robinson

      Pages 101-111

   4. Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region

      • Gunnar Wichmann

      Pages 113-122

   5. Tumor Staging and HPV-Related Oropharyngeal Cancer

      • Claus Wittekindt, Jens Peter Klussmann

      Pages 123-133

4. Non-Surgical Treatment of HPV Positive Tumours

   1. Front Matter

      Pages 135-135

      PDF

   2. Human Papillomavirus (HPV): A Criterion for Therapeutic Decision in Squamous Cell Carcinoma of the Head and Neck?

      • Jan B. Vermorken

      Pages 137-147

   3. Systemic Treatment in HPV-Induced Recurrent or Metastatic HNSCC

      • Damian T. Rieke, Ulrich Keilholz

      Pages 149-160

   4. Optimizing Radiotherapy in HPV-Associated Oropharyngeal Cancer Patients

      • Johannes A. Langendijk, Roel J.H.M. Steenbakkers

      Pages 161-171

   5. Should We De-escalate the Treatment for HPV-Positive Tumors?

      • Andreas Dietz, Gunnar Wichmann, Susanne Wiegand

      Pages 173-181

5. Surgical Treatment of HPV Positive Tumours

   1. Front Matter

      Pages 183-183

      PDF

   2. The Role of Conventional Surgery in Oropharyngeal Cancer

      • Wojciech Golusinski

      Pages 185-195

   3. The Role of Surgery in the Management of Recurrent Oropharyngeal Cancer

      • Neil D. Gross, Ehab Y. Hanna

      Pages 197-205

This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.

• De-escalation of HPV
• Epidemiology of HPV
• Head and Neck Cancer
• Molecular Biology of HPV
• Testing of HPV
• Treatment of HPV
• head and neck surgery

• Department of Head and Neck Surgery, Poznan University of Medical Sciences, The Greater Poland Cancer Centre, Poznań, Poland

  Wojciech Golusiński

• Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center/Cancer Center Amsterdam, Amsterdam, The Netherlands

  C. René Leemans

• Dept. of Head Medicine and Oral Health, University of Leipzig Clinic of Otolaryngology, Leipzig, Germany

  Andreas Dietz

Policies and ethics