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Biomarkers of the Tumor Microenvironment

Basic Studies and Practical Applications

  • Book
  • © 2017

Overview

Editors:
  1. Lars A. Akslen

    1. Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway

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  2. Randolph S. Watnick

    1. Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers basic model studies of novel biomarkers and treatment targets of the microenvironment, exploration and validation of different classes of biomarkers in human tumors, and challenges of clinical implementation and treatment trials

  • High-quality illustrations and colour images of tissue-based biomarkers

  • International authors and opinion leaders in different research fields

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Basic Mechanisms and Biomarkers

    1. Front Matter

      Pages 1-1
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    2. The Role of the Tumor Microenvironment in Regulating Angiogenesis

      • Randolph S. Watnick
      Pages 3-23

    3. More Than a Barrier: How the Endothelium Instructs Metastasis

      • Candice Alexandra Grzelak, Andrea Rachel Lim, Cyrus Michael Ghajar
      Pages 25-53

    4. Tissue-Based Biomarkers of Tumor-Vascular Interactions

      • Lars A. Akslen
      Pages 55-75

    5. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?

      • Cédric Zeltz, Roya Navab, Marion Kusche-Gullberg, Ming-Sound Tsao, Donald Gullberg
      Pages 77-112

    6. Stromal PDGF Receptors as Prognostic and Predictive Biomarkers

      • Arne Östman
      Pages 113-128

    7. The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment

      • Joan Chang, Andrew C. Dudley
      Pages 129-166

    8. Inflammation and Cancer: The Role of Lipid Signaling in the Continuum Between Two Ends of the Tumor Spectrum

      • Megan L. Sulciner, Molly M. Gilligan, Bruce R. Zetter, Dipak Panigrahy
      Pages 167-193

    9. Cancer Immunity and Immune Evasion Mechanisms

      • Stalin Chellappa, Einar M. Aandahl, Kjetil Taskén
      Pages 195-220

    10. Drivers of EMT and Immune Evasion

      • Rolf A. Brekken, Katarzyna Wnuk-Lipinska
      Pages 221-239

    11. Inflammatory Biomarkers for Cancer

      • Alexandre Corthay, Guttorm Haraldsen
      Pages 241-257

    12. Immunology of Solid Tumors Beyond Tumor-Infiltrating Lymphocytes: The Role of Tertiary Lymphoid Structures

      • Gert G. G. M. Van den Eynden, Roberto Salgado, Karen Willard-Gallo
      Pages 259-280

    13. The Role of Platelets in the Tumor Microenvironment

      • Kelly E. Johnson, Sandra S. McAllister, Joseph E. Italiano Jr., Elisabeth M. Battinelli
      Pages 281-302

    14. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments

      • Tina El Rayes, Dingcheng Gao, Nasser K. Altorki, Thomas R. Cox, Janine T. Erler, Vivek Mittal
      Pages 303-328

    15. Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis

      • Xiaoran Li, Diane R. Bielenberg
      Pages 329-349

    16. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance

      • Kjersti T. Davidsen, Gry S. Haaland, Maria K. Lie, James B. Lorens, Agnete S. T. Engelsen
      Pages 351-376

  3. Organ Related Biomarker Studies

    1. Front Matter

      Pages 377-377
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    2. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer

      • Elisabeth Wik, Lars A. Akslen
      Pages 379-407

    3. MR-Derived Biomarkers for Cancer Characterization

      • Eugene Kim, Morteza Esmaeili, Siver A. Moestue, Tone F. Bathen
      Pages 409-431
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Keywords

About this book

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. 

Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

Editors and Affiliations

  • Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway

    Lars A. Akslen

  • Vascular Biology Program, Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, USA

    Randolph S. Watnick

About the editors

Lars A. Akslen, M.D., Ph.D., Centre for Cancer Biomarkers, Department of Clinical Medicine, The Gade Laboratory for Pathology University of Bergen, NORWAY Randolph S. Watnick, Ph.D., Assistant Professor, Department of Surgery, Harvard Medical School, Vascular Biology Program, Boston Children's Hospital Boston, USA

Bibliographic Information

  • Book Title: Biomarkers of the Tumor Microenvironment

  • Book Subtitle: Basic Studies and Practical Applications

  • Editors: Lars A. Akslen, Randolph S. Watnick

  • DOI: https://doi.org/10.1007/978-3-319-39147-2

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Softcover ISBN: 978-3-319-81829-0Published: 03 August 2018

  • eBook ISBN: 978-3-319-39147-2Published: 02 August 2017

  • Edition Number: 1

  • Number of Pages: XVII, 534

  • Number of Illustrations: 1 b/w illustrations, 51 illustrations in colour

  • Topics: Pathology, Cancer Research

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