Genomic Instability and Cancer Metastasis

1. Front Matter

   Pages i-x

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2. Cancer Metastasis: Tracking and Attacking a Moving Target

   • David I. Rodenhiser, Ann F. Chambers

   Pages 1-13

3. The Generation, Detection, and Prevention of Genomic Instability During Cancer Progression and Metastasis

   • Helen Chen, Christopher Maxwell, Marisa Connell

   Pages 15-38

4. DNA Damage Response Pathways in Cancer Predisposition and Progression

   • Mohamed E. Ashour, Lamia El-Shafie, Sherif F. El-Khamisy

   Pages 39-74

5. Mathematical Modeling for DNA Repair, Carcinogenesis and Cancer Detection

   • Jonathan Tang, Walter Georgescu, Thomas Deschamps, Steven M. Yannone, Sylvain V. Costes

   Pages 75-93

6. Animal Models of Metastasis

   • Dawn R Cochrane, Dong Lin, Graham Dellaire, Elizabeth C Halvorsen, Jason N Berman, Yuzhou Wang et al.

   Pages 95-123

7. Microenvironmental Control of Metastatic Progression

   • Calvin D. Roskelley

   Pages 125-137

8. Mechanotransduction, Metastasis and Genomic Instability

   • Allison K. Simi, Alexandra S. Piotrowski, Celeste M. Nelson

   Pages 139-158

9. Immunomodulation and Genomic Instability

   • Gregor Reid

   Pages 159-177

10. Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability

    • Babu V. Sajesh, Amy L. Cisyk, Kirk J. McManus

    Pages 179-204

11. Nanomedicine—Nanoparticles in Cancer Imaging and Therapy

    • Alexandra M. N. Hauser-Kawaguchi, Leonard G. Luyt

    Pages 205-244

12. Back Matter

    Pages 245-247

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Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

• Cancer Metastasis
• DNA damage response
• Genomic instability
• Therapeutic approaches
• Tumor heterogeneity

“This book connects cancer metastasis, the major cause of death in patients with malignancy, with genomic instability. For oncologists and biologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (4), 2015)

• Child & Family Research Institute, University of British Columbia, Pediatrics, Vancouver, Canada

  Chris Maxwell

• Dept of Cellular & Physiological Sciences, University of British Columbia, Dept. of Cellular & Physiological Sciences, Vancouver, Canada

  Cal Roskelley

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