Overview
- Covers the molecular mechanisms underlying autophagy in inflammation
- Discusses opportunities to target autophagy as a novel therapeutic strategy against inflammation-based diseases
- Provides an overview on clinical trials
Part of the book series: Progress in Inflammation Research (PIR)
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Table of contents (17 chapters)
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Front Matter
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Molecular Mechanisms Underlying Autophagy in Inflammation
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Front Matter
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Targeting Autophagy as a Novel Therapeutic Strategy in Inflammation-Based Pathologies
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Front Matter
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Keywords
About this book
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions ofthe autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
Editors and Affiliations
Bibliographic Information
Book Title: Autophagy Networks in Inflammation
Editors: Maria Chiara Maiuri, Daniela De Stefano
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-319-30079-5
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-30077-1Published: 25 August 2016
Softcover ISBN: 978-3-319-80719-5Published: 09 June 2018
eBook ISBN: 978-3-319-30079-5Published: 17 August 2016
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XV, 403
Number of Illustrations: 4 b/w illustrations, 16 illustrations in colour
Topics: Immunology, Cell Biology, Infectious Diseases