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Microsystems for Enhanced Control of Cell Behavior

Fundamentals, Design and Manufacturing Strategies, Applications and Challenges

  • Book
  • © 2016

Overview

Editors:
  1. Andrés Díaz Lantada

    1. Mechanical Engineering, Universidad Politecnica de Madrid, Madrid, Spain

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  • Offers a systematic compilation of biomedical microsystems that promote special interactions with cells
  • Details design and manufacturing strategies
  • Describes more than 40 case studies on microsystem development
  • Includes computer-aided design files and simulation files as supplementary material
  • Includes supplementary material: sn.pub/extras

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials (SMTEB, volume 18)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Fundamentals

    1. Front Matter

      Pages 1-1
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    2. Some Introductory Notes to Cell Behavior

      • Andrés Díaz Lantada
      Pages 3-14

    3. Brief Introduction to the Field of Biomedical Microsystems

      • Andrés Díaz Lantada
      Pages 15-24

    4. Brief Introduction to Biomedical Microsystems for Interacting with Cells

      • Andrés Díaz Lantada
      Pages 25-36

    5. State-of-the-Art Bioengineering Resources for Interacting with Cells

      • Andrés Díaz Lantada
      Pages 37-45

  3. Design and Manufacturing Technologies and Strategies

    1. Front Matter

      Pages 47-47
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    2. Systematic Methodologies for the Development of Biomedical Microdevices

      • Andrés Díaz Lantada
      Pages 49-65

    3. Addressing the Complexity of Biomaterials by Means of Biomimetic Computer Aided Design

      • Andrés Díaz Lantada
      Pages 67-92

    4. Multi-scale and Multi-physical/Biochemical Modeling in Bio-MEMS

      • Andrés Díaz Lantada
      Pages 93-114

    5. Rapid Prototyping of Biomedical Microsystems for Interacting at a Cellular Level

      • Andrés Díaz Lantada, Jeffrey Resnick, Javier Mousa, Miguel Ángel de Alba, Stefan Hengsbach, Milagros Ramos Gómez
      Pages 115-145

    6. Nanomanufacturing Technologies for Biomedical Microsystems Interacting at a Molecular Scale

      • Andrés Díaz Lantada, Jose Luis Endrino
      Pages 147-162

    7. Issues Linked to the Mass-Production of Biomedical Microsystems

      • Andrés Díaz Lantada
      Pages 163-174

  4. Applications

    1. Front Matter

      Pages 175-175
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    2. Biomedical Microsystems for Disease Management

      • Andrés Díaz Lantada, Pilar Lafont Morgado, Pedro Ortego García
      Pages 177-189

    3. Overview of Microsystems for Studying Cell Behavior Under Culture

      • Andrés Díaz Lantada, Alberto Bustamante, Alisa Morss Clyne, Rebecca Urbano, Adam C. Canver, Josefa Predestinación García Ruíz et al.
      Pages 191-208

    4. Microstructured Devices for Studying Cell Adhesion, Dynamics and Overall Mechanobiology

      • Andrés Díaz Lantada, Adrián de Blas Romero, Josefa Predestinación García Ruíz, Hernán Alarcón Iniesta, Stefan Hengsbach, Volker Piotter
      Pages 209-225

    5. Smart Microsystems for Active Cell Culture, Growth and Gene Expression Toward Relevant Tissues

      • Andrés Díaz Lantada, Enrique Colomer Mayola, María Consuelo Huerta Gómez de Merodio, Alban Muslija, Josefa Predestinación García Ruíz, Hernán Alarcón Iniesta
      Pages 227-247

    6. Tissue Engineering Scaffolds for 3D Cell Culture

      • Andrés Díaz Lantada, Diego Curras, Javier Mousa, Stefan Hengsbach
      Pages 249-268

    7. Tissue Engineering Scaffolds for Bone Repair: General Aspects

      • Andrés Díaz Lantada, Adrián de Blas Romero, Santiago Valido Moreno, Diego Curras, Miguel Téllez, Martin Schwentenwein et al.
      Pages 269-285
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Keywords

About this book

This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.

Editors and Affiliations

  • Mechanical Engineering, Universidad Politecnica de Madrid, Madrid, Spain

    Andrés Díaz Lantada

About the editor

Andrés Díaz Lantada is Associate Professor at Technical University of Madrid (UPM), Spain, teaching 'Design and manufacture with polymers', 'Computer-aided engineering', and 'Bioengineering. He carries out research at the UPM Product Development Laboratory linked to the development of biomedical devices based on smart/multifunctional materials, biomimetic fractal and non-Euclidean designs, and mechanical metamaterials for enhanced performance and adequate tissue interaction.

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