Editors:
- Provides the most recent and relevant advances in molecular radiobiology of glioblastoma, and the related possible changes in the clinical setting
- Written by experts in the field
- Bridges the gap of knowledge and methodology in approaching RB of GB between basic researchers and clinical investigators
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Clinical Pathology (CCPATH)
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Table of contents (19 chapters)
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Front Matter
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From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies
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Front Matter
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Preclinical Research
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Front Matter
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From Bench to Bedside: Translational Perspectives
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Front Matter
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About this book
This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models.
Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.
Reviews
Editors and Affiliations
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University of Siena, Sec. of Radiation Oncology,Dept. of Med., Siena, Italy
Luigi Pirtoli
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Dept. of Applied Clinical & Biotech Sci., University of L’Aquila, L’Aquila, Italy
Giovanni Luca Gravina
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Department of Biology, Temple University, Philadelphia, USA
Antonio Giordano
About the editors
Department of Medicine, Surgery and Neurosciences
University of Siena
Siena, Italy
Dr. Giovanni Luca Gravina
Department of Biology and Biotechnology
University of Pavia
Rome, Italy
Antonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology
Temple University
Philadelphia, PA, USA
Department of Medicine, Surgery & Neurosciences
University of Siena
Siena, Italy
Bibliographic Information
Book Title: Radiobiology of Glioblastoma
Book Subtitle: Recent Advances and Related Pathobiology
Editors: Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano
Series Title: Current Clinical Pathology
DOI: https://doi.org/10.1007/978-3-319-28305-0
Publisher: Humana Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-28303-6Published: 16 June 2016
Softcover ISBN: 978-3-319-80321-0Published: 30 May 2018
eBook ISBN: 978-3-319-28305-0Published: 06 June 2016
Series ISSN: 2197-781X
Series E-ISSN: 2197-7828
Edition Number: 1
Number of Pages: XX, 305
Number of Illustrations: 10 b/w illustrations, 39 illustrations in colour