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NF-κB-Related Genetic Diseases

  • Book
  • © 2016

Overview

Authors:
  1. Gilles Courtois

    1. CEA Grenoble, INSERMU1038, iRTSV, Grenoble, France

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  2. Alessandra Pescatore

    1. Biophysics, IGB-CNR, International Institute of Genetics and, Naples, Italy

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  3. Jérémie Gautheron

    1. Department of Gastroenterology, University Hospital RWTH Aachen, Aachen, Germany

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  4. Francesca Fusco

    1. Biophysics, IGB-CNR, International Institute of Genetics and, Naples, Italy

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  5. Matilde Valeria Ursini

    1. Biophysics, IGB-CNR, International Institute of Genetics and, Naples, Italy

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  6. Anna Senegas

    1. CEA Grenoble, INSERMU1038, iRTSV, Grenoble, France

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  • Presents an overview of NF-kB-related genetic diseases
  • Enables understanding of underlying pathophysiology
  • Complements results from animal studies
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology (BRIEFSBIOCHEM)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xii
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  2. The NF-κB Signaling Pathway: Players and Functions

    • Gilles Courtois, Alessandra Pescatore, Jérémie Gautheron, Francesca Fusco, Matilde Valeria Ursini, Anna Senegas
    Pages 1-21

  3. Genetic Diseases Affecting the Canonical Pathway of NF-κB Activation

    • Gilles Courtois, Alessandra Pescatore, Jérémie Gautheron, Francesca Fusco, Matilde Valeria Ursini, Anna Senegas
    Pages 23-47

  4. Genetic Diseases Affecting the Non-canonical Pathway of NF-κB Activation

    • Gilles Courtois, Alessandra Pescatore, Jérémie Gautheron, Francesca Fusco, Matilde Valeria Ursini, Anna Senegas
    Pages 49-55

  5. Genetic Diseases Affecting Ubiquitination Processes in NF-κB Signaling

    • Gilles Courtois, Alessandra Pescatore, Jérémie Gautheron, Francesca Fusco, Matilde Valeria Ursini, Anna Senegas
    Pages 57-64

  6. Lessons Learned from Studying NF-κB-Related Genetic Diseases

    • Gilles Courtois, Alessandra Pescatore, Jérémie Gautheron, Francesca Fusco, Matilde Valeria Ursini, Anna Senegas
    Pages 65-70
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Keywords

About this book

This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

Reviews

“This book provides essential concepts in the understanding of the impact of deregulated NF-kappaB activation on human health. … This book is intended for molecular biologists, human geneticists, and students interested in learning more about NF-kappaB signaling and its impact on human disease. The book is also useful for pathologists and clinicians interested in understanding more about this topic. … Several color illustrations help in the understanding of this complex subject.” (Omer Iqbal, Doody’s Book Reviews, April, 2016)

Authors and Affiliations

  • CEA Grenoble, INSERMU1038, iRTSV, Grenoble, France

    Gilles Courtois, Anna Senegas

  • Biophysics, IGB-CNR, International Institute of Genetics and, Naples, Italy

    Alessandra Pescatore, Francesca Fusco, Matilde Valeria Ursini

  • Department of Gastroenterology, University Hospital RWTH Aachen, Aachen, Germany

    Jérémie Gautheron

About the authors

Gilles Courtois (INSERM) and colleagues are performing genetic research at the Institut des Neurosciences de Grenoble. They have demonstrated details of the NF-kB signaling pathway and collaborate on publications about Incontinentia Pigmenti, a genetic disease of the skin, hair, teeth and central nervous system. He and his team are working with the group of Annie Andrieux and Eric Denarier on mice lacking the NEMO protein, one component of the signal cascade, exclusively in their nervous system or throughout their body. The studies focus on neurological problems but will provide insight into the signaling pathway from different angles.

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