Overview
- Summarizes current research on the BRICHOS domain
- Discusses the mechanisms by which BRICHOS inhibits Aß aggregation
- Explores the potential of using the BRICHOS domain in the fight against Alzeimer's Disease
- Includes supplementary material: sn.pub/extras
Part of the book series: SpringerBriefs in Molecular Science (BRIEFSMOLECULAR)
Part of the book sub series: Protein Folding and Structure (BRIEFSPROTEIN)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (1 chapter)
Keywords
About this book
Authors and Affiliations
About the authors
Jenny Presto obtained her PhD in Medical Biochemistry from Uppsala University in 2006, where she studied the biosynthesis of heparan sulfate. She did a postdoc at the Swedish University of Agricultural Sciences (SLU) in Uppsala, Sweden, studying the function of the BRICHOS domain as a chaperone for surfactant protein C.
In 2011, Jenny moved to Karolinska Institutet, Center for Alzheimer Research, Stockholm, Sweden, where she currently is assistant professor. Her research focuses on the in vitro and in vivo inhibition of amyloid-b fibril formation and toxicity by the chaperone BRICHOS.
Jan Johansson obtained his MD from Karolinska Institutet in 1990, and got a PhD from Karolinska Institutet 1991. He spent a post-doc with Kurt Wüthrich at the ETH in Zürich during 1992 and 1993, which resulted on the first structure determination of a lung surfactant protein. He is currently professor of Biological Dementia Research at Karolinska Institutet and of Medical Biochemistry at the Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
Johansson’s research has generated synthetic proteins for treatment of respiratory distress and has led to identification of fundamental properties of amyloidogenic proteins, defined a novel type of chaperone defense involved in amyloid diseases and revealed pathways to control protein assembly in spider silk formation.
Bibliographic Information
Book Title: The BRICHOS Domain
Book Subtitle: Its Proproteins and Functions
Authors: Jenny Presto, Jan Johansson
Series Title: SpringerBriefs in Molecular Science
DOI: https://doi.org/10.1007/978-3-319-16564-6
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Author(s) 2015
Softcover ISBN: 978-3-319-16563-9Published: 17 April 2015
eBook ISBN: 978-3-319-16564-6Published: 12 March 2015
Series ISSN: 2191-5407
Series E-ISSN: 2191-5415
Edition Number: 1
Number of Pages: XV, 28
Number of Illustrations: 13 illustrations in colour
Topics: Bioorganic Chemistry, Protein Structure