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Protein Kinase CK2 Cellular Function in Normal and Disease States

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  • © 2015

Overview

Editors:
  1. Khalil Ahmed

    1. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, USA

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  2. Olaf-Georg Issinger

    1. Dept of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  3. Ryszard Szyszka

    1. Department of Molecular Biology, The John Paul II Catholic U. of Lublin Institute of Biotechnology, Lublin, Poland

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    You can also search for this editor in PubMed   Google Scholar

  • CK2 is a potential target of drug development for improved cancer therapy
  • State-of-the-art information on the critical role of CK2 in cellular function and cancer biology?
  • Crucial tool for post-graduate students and investigators in the field of cancer biology

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 12)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Regulation and Structure–Function Studies of CK2

    1. Front Matter

      Pages 1-1
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    2. Yeast Asf1 Protein as Modulator of Protein Kinase CK2 Activity

      • Andrea Baier, Ewa Alikowska, Ryszard Szyszka
      Pages 3-16

    3. Impressions from the Conformational and Configurational Space Captured by Protein Kinase CK2

      • Jennifer Hochscherf, Alexander Schnitzler, Olaf-Georg Issinger, Karsten Niefind
      Pages 17-33

    4. Structural Basis of CK2 Regulation by Autoinhibitory Oligomerization

      • Graziano Lolli, Roberto Battistutta
      Pages 35-47

    5. Maize RNA-Binding Protein ZmTGH: A New Partner for CK2β1 Regulatory Subunit

      • Isabel Cristina Vélez-Bermúdez, Marta Riera
      Pages 49-55

  3. CK2 Control of Organismal and Cellular Functions

    1. Front Matter

      Pages 57-57
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    2. CK2 in Organ Development, Physiology, and Homeostasis

      • Charina E. Ortega, Lawrence Prince-Wright, Isabel Dominguez
      Pages 59-79

    3. Protein Kinase CK2: A Window into the Posttranslational Regulation of the E(spl)/HES Repressors from Invertebrates and Vertebrates

      • Adam T. Majot, Tyler R. Sizemore, Mohna Bandyopadhyay, Lucas M. Jozwick, Ashok P. Bidwai
      Pages 81-107

    4. Tissue-Specific Functions and Regulation of Protein Kinase CK2

      • Sabrina Welker, Christina Servas, Meng Rui, Claudia Götz, Mathias Montenarh
      Pages 109-123

    5. CK2 Function in the Regulation of Akt Pathway

      • Cristina Girardi, Maria Ruzzene
      Pages 125-140

    6. Cellular Zinc Signalling Is Triggered by CK2

      • Thirayost Nimmanon, Kathryn M. Taylor
      Pages 141-157

    7. CK2: A Global Regulator of Cell Death

      • Janeen H. Trembley, Fatima Qaiser, Betsy T. Kren, Khalil Ahmed
      Pages 159-181

    8. Protein Kinase CK2: Systematic Relationships with Other Posttranslational Modifications

      • David W. Litchfield, Laszlo Gyenis
      Pages 183-196

    9. Role for Protein Kinase CK2 on Cell Proliferation: Assessing CK2 Complex Components in the Nucleus During the Cell Cycle Progression

      • Miwako Kato Homma, Takeshi Shibata, Toshiyuki Suzuki, Masato Ogura, Hiroko Kozuka-Hata, Masaaki Oyama et al.
      Pages 197-226

    10. “Genuine” Casein Kinase: The False Sister of CK2 That Phosphorylates Secreted Proteins at S-x-E/pS Motifs

      • Elena Tibaldi, Giorgio Arrigoni, Giorgio Cozza, Luca Cesaro, Lorenzo A. Pinna
      Pages 227-237

  4. Function of CK2 in Cancer and Its Therapeutic Targeting

    1. Front Matter

      Pages 239-239
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    2. Dysregulated Expression of Protein Kinase CK2 in Renal Cancer

      • Caroline Roelants, Sofia Giacosa, Eve Duchemin-Pelletier, Anne McLeer-Florin, Céline Tisseyre, Cédric Aubert et al.
      Pages 241-257

    3. Protein Kinase CK2 and Dysregulated Oncogenic Inflammatory Signaling Pathways

      • Etty N. Benveniste, G. Kenneth Gray, Braden C. McFarland
      Pages 259-280

    4. CIGB-300: A Promising Anti-Casein Kinase 2 (CK2) Peptide for Cancer Targeted Therapy

      • Silvio E. Perea, Yasser Perera, Idania Baladrón, Lidia González, Fernando Benavent, Hernán G. Fariña et al.
      Pages 281-298
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Keywords

About this book

Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research. ​

Editors and Affiliations

  • Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, USA

    Khalil Ahmed

  • Dept of Biochemistry & Molecular Biology, University of Southern Denmark, Odense, Denmark

    Olaf-Georg Issinger

  • Department of Molecular Biology, The John Paul II Catholic U. of Lublin Institute of Biotechnology, Lublin, Poland

    Ryszard Szyszka

About the editors

Dr. Khalil Ahmed is a Professor at the University of Minnesota, and a Senior Research Career Scientist at Minneapolis VA Health Care System, Minneapolis, Minnesota, U.S.A. He has a long history of studies on the functional biology of protein kinase CK2 in normal and neoplastic cells. He originally described the signal mediated dynamic shuttling of CK2 in the cell, and discovered the role of CK2 as a suppressor of apoptosis. His current research is focused on the mechanism of CK2 regulation of cell death. He is also studying the development of molecular therapeutic strategies using a nanomedicine approach for treatment of prostate and other cancers.

Dr. Olaf-Georg Issinger is a Professor at the University of Southern Denmark, Odense, Denmark. He has been involved in the initial cloning and characterization of protein kinase CK2, a prerequisite for the elucidation of its structure in the absence and presence of specific interaction molecules. His current research focuses on the exploration of cellular signaling pathways in cell lines with respect to the role of various protein kinases using newly characterized kinase inhibitors identified by screening small chemical compound libraries.

Dr. Ryszard Szyszka is a Professor at the John Paul II Catholic University of Lublin, Poland. He is head of the Department of Molecular Biology and Dean of the Faculty of Biotechnology and Environmental Sciences. His research is focused on the identification and characterization of new substrates of protein kinase CK2 from Saccharomyces cerevisiae. Further areas of interest include the structure and regulation of yeast CK2, and discovery of novel CK2 inhibitors. 

Bibliographic Information

  • Book Title: Protein Kinase CK2 Cellular Function in Normal and Disease States

  • Editors: Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka

  • Series Title: Advances in Biochemistry in Health and Disease

  • DOI: https://doi.org/10.1007/978-3-319-14544-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-14543-3Published: 25 March 2015

  • Softcover ISBN: 978-3-319-37986-9Published: 06 October 2016

  • eBook ISBN: 978-3-319-14544-0Published: 03 March 2015

  • Series ISSN: 2512-2142

  • Series E-ISSN: 2512-2150

  • Edition Number: 1

  • Number of Pages: XXIII, 378

  • Number of Illustrations: 31 b/w illustrations, 60 illustrations in colour

  • Topics: Cancer Research, Protein Science, Apoptosis

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