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Genomic Instability and Cancer Metastasis

Mechanisms, Emerging Themes, and Novel Therapeutic Strategies

  • Book
  • © 2015

Overview

Editors:
  1. Chris Maxwell

    1. Child & Family Research Institute, University of British Columbia, Pediatrics, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Cal Roskelley

    1. Dept of Cellular & Physiological Sciences, University of British Columbia, Dept. of Cellular & Physiological Sciences, Vancouver, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Connects cancer metastasis with genomic instability in a comprehensive manner
  • Outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes
  • Reviews emerging themes and highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Metastasis - Biology and Treatment (CMBT, volume 20)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Cancer Metastasis: Tracking and Attacking a Moving Target

    • David I. Rodenhiser, Ann F. Chambers
    Pages 1-13

  3. The Generation, Detection, and Prevention of Genomic Instability During Cancer Progression and Metastasis

    • Helen Chen, Christopher Maxwell, Marisa Connell
    Pages 15-38

  4. DNA Damage Response Pathways in Cancer Predisposition and Progression

    • Mohamed E. Ashour, Lamia El-Shafie, Sherif F. El-Khamisy
    Pages 39-74

  5. Mathematical Modeling for DNA Repair, Carcinogenesis and Cancer Detection

    • Jonathan Tang, Walter Georgescu, Thomas Deschamps, Steven M. Yannone, Sylvain V. Costes
    Pages 75-93

  6. Animal Models of Metastasis

    • Dawn R Cochrane, Dong Lin, Graham Dellaire, Elizabeth C Halvorsen, Jason N Berman, Yuzhou Wang et al.
    Pages 95-123

  7. Microenvironmental Control of Metastatic Progression

    • Calvin D. Roskelley
    Pages 125-137

  8. Mechanotransduction, Metastasis and Genomic Instability

    • Allison K. Simi, Alexandra S. Piotrowski, Celeste M. Nelson
    Pages 139-158

  9. Immunomodulation and Genomic Instability

    • Gregor Reid
    Pages 159-177

  10. Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability

    • Babu V. Sajesh, Amy L. Cisyk, Kirk J. McManus
    Pages 179-204

  11. Nanomedicine—Nanoparticles in Cancer Imaging and Therapy

    • Alexandra M. N. Hauser-Kawaguchi, Leonard G. Luyt
    Pages 205-244

  12. Back Matter

    Pages 245-247
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Keywords

About this book

Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

Reviews

“This book connects cancer metastasis, the major cause of death in patients with malignancy, with genomic instability. For oncologists and biologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (4), 2015)

Editors and Affiliations

  • Child & Family Research Institute, University of British Columbia, Pediatrics, Vancouver, Canada

    Chris Maxwell

  • Dept of Cellular & Physiological Sciences, University of British Columbia, Dept. of Cellular & Physiological Sciences, Vancouver, Canada

    Cal Roskelley

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