Skip to main content
Springer Nature Link
Log in

Metallointercalators

Synthesis and Techniques to Probe Their Interactions with Biomolecules

  • Book
  • © 2011

Overview

Editors:
  1. Janice Aldrich-Wright

    1. School of Biomedical & Health Sciences, University of Western Sydney, Penrith South DC, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a detailed exposition on the propaedeutics and techniques illustrated with cogent examples
  • Includes supplementary material: sn.pub/extras

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

About this book

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Similar content being viewed by others

Keywords

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xxviii
    Download chapter PDF

  2. Target Biological Structures: The Cell, Organelles, DNA and RNA

    • Marcelis van Holst, Maxine P. Grant, Janice Aldrich-Wright
    Pages 1-25

  3. Ruthenium Polypyridyl Metallointercalators

    • Nikita Orkey, Paul Wormell, Janice Aldrich-Wright
    Pages 27-67

  4. The Synthesis of Platinum(II) Intercalators

    • Anwen M. Krause-Heuer, Madhura Manohar, K. Benjamin Garbutcheon-Singh, Dianne M. Fisher, Janice Aldrich-Wright
    Pages 69-100

  5. Platinum(II) Intercalating Complexes Based on 2,2′:6′,2″-Terpyridine

    • Benjamin W. J. Harper, Marcelis van Holst, Janice Aldrich-Wright
    Pages 101-128

  6. Introduction to Nuclear Magnetic Resonance

    • Allan M. Torres, William S. Price
    Pages 129-141

  7. NMR Studies of Metallointercalator–DNA Interactions

    • Damian P. Buck, J. Grant Collins
    Pages 143-157

  8. Pulsed Gradient Spin-Echo NMR

    • Gang Zheng, Anwen M. Krause-Heuer, William S. Price
    Pages 159-185

  9. Mass Spectrometric Studies of Non-Covalent Binding Interactions Between Metallointercalators and DNA

    • Thitima Urathamakul, Jihan Talib, Jennifer L. Beck, Stephen F. Ralph
    Pages 187-213

  10. Investigating Binding Interactions Using Linear Dichroism and Circular Dichroism

    • Alison Rodger, Per Lincoln
    Pages 215-234

  11. Applications of Fluorescence Spectroscopy and Confocal Microscopy

    • Anya Salih, Paul Wormell, K. Benjamin Garbutcheon-Singh, Benjamin Harper, Simon Myers, David Geny et al.
    Pages 235-272

  12. Synchrotron Radiation X-Ray Spectroscopy for Investigations of Intracellular Metallointercalators: X-Ray Fluorescence Imaging and X-Ray Absorption Spectroscopy

    • Carolyn T. Dillon
    Pages 273-298

  13. The Use of Calorimetry to Study Ligand–DNA Interactions

    • Nichola C. Garbett
    Pages 299-324

  14. Investigating the Biological Significance of Metallointercalators with cDNA Microarrays

    • Elise P. Wright, Victoria Lyons, Shaoyu Wang, Vincent J. Higgins
    Pages 325-359

  15. Cytotoxicity Testing: Cell Experiments

    • Renate Grünert, Aron Westendorf, Magdalena Buczkowska, Mareike Hänsch, Sybil Grüunert, Patrick J. Bednarski
    Pages 361-372

  16. Development of Metal Complexes as Potential Antimicrobials

    • Albert Bolhuis, Adair D. Richards
    Pages 373-388

  17. Animal Testing

    • Johnny Moretto, Bruno Chauffert, Florence Bouyer
    Pages 389-416

  18. Back Matter

    Pages 417-427
    Download chapter PDF
Back to top

Editors and Affiliations

  • School of Biomedical & Health Sciences, University of Western Sydney, Penrith South DC, Australia

    Janice Aldrich-Wright

Bibliographic Information

Publish with us

Policies and ethics

Back to top