Oxidative Stress, Cell Activation and Viral Infection

1. Front Matter

   Pages I-XI

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2. DNA Glycosylases Involved in the Repair of Oxidized Bases in Escherichia coli

   • S. Boiteux

   Pages 1-8

3. Potential Role of Protein Oxidation and Proteasome in Antigen Processing

   • K. J. A. Davies

   Pages 9-19

4. Involvement of hydrogen peroxide in the actions of TGFβ1

   • K. Nose, M. Ohba, M. Shibanuma, T. Kuroki

   Pages 21-34

5. Oxidative Stress and Growth Factor-Mediated Signal Transduction

   • A. Stern

   Pages 35-42

6. Cellularly generated active oxygen species as signals in the activation of tumour cell growth

   • R. H. Burdon

   Pages 43-52

7. Effect of oxygen radicals on the IL-1 production by monocytes and IL-2 receptor expression in lymphocytes during primary and secondary immunodeficiency

   • I. B. Afanas’ev, L. G. Korkina

   Pages 53-58

8. The effect of reactive oxygen species (ROS) on human T and B lymphoid cells

   • B. M. Hannigan, S. Ranjbar, L. Cromie

   Pages 59-63

9. Leukocyte Adhesion and Endothelial Cytokine Production in Hypoxia /Reoxygenation

   • G. Modat, C. Bonne, J. Dornand

   Pages 65-75

10. Effects of Antioxidants on IL-6 Secretion Induced by IL-1 in Human Cultured Lung Fibroblasts. Involvement of NFκB

    • M. Raes, P. Renard, E. Bosmans, E. Delaive, J. Remacle

    Pages 77-90

11. Hydrogen peroxide-induced synthesis of the 32kDa stress protein (HO-1) in endothelial cells is serum dependent

    • V. R. Winrow, A. Watson, S. L. Harley, D. R. Blake

    Pages 91-100

12. The Antioxidant Effects of Glutathione and Ascorbic Acid

    • A. Meister

    Pages 101-111

13. Structural consequences of NF-κB inhibition by natural antioxidants: α-lipoic acid and vitamin E

    • L. Packer, Y. J. Suzuki

    Pages 113-130

14. d-α-Tocopherol and Cell Proliferation

    • A. Azzi, D. Boscoboinik, E. Chatelain, Nesrin K. Özer, Barbara Stäuble

    Pages 131-141

15. Effects of Intracellular Redox Status on Cellular Regulation and Viral Infection

    • G. Rotilio, L. Knoepfel, C. Steinkuhler, A. T. Palamara, M. R. Ciriolo, E. Garaci

    Pages 143-153

16. Mechanisms of Regulation of Cell Growth by Cytokines of the Immune System

    • B. B. Aggarwal, K. Totpal

    Pages 155-163

17. Oxidization of human low density lipoproteins measured by Laser Doppler electrophoresis

    • D. Bonnefont-Rousselot, B. Arrio, J. Catudioc, L. Packer

    Pages 165-171

18. Selective modulation of brain antioxidant defense capacity by genetic or metabolic manipulations

    • M. Merad-Boudia, L. Fideler, A. Nicole, B. Aral, P. M. Sinet, P. Briand et al.

    Pages 173-192

19. Protective effect of Poly(A)-Poly(U) against immune oxidative injury. Role of thiols released by activated macrophages

    • M. Fay, M. Jampy-Fay, K. Akarid, M. A. Gougerot-Pocidalo

    Pages 193-201

20. Reactive oxygen, antioxidants, and autotoxicity in viral diseases

    • E. Peterhans

    Pages 203-215

Since the appearance of photosynthesis on our planet, all living organisms have been facing a new abundant, extremely reactive element, oxygen. This element is used for the synthesis of highly energetic compounds, but can also generate molecules capable of damaging constituents of living structures, including proteins, nucleic acids and lipids. It is therefore no surprise that all biological organisms have evolved multiple and sophisticated ways to reduce the detrimental effects of oxygen. For cells and tissues of highly organized animals, particularly cells of the immune system, superoxidation products play an important role, via oxidative stress, in activation, inflammation and viral and bacterial infections. We must be grateful to Drs. C. Pasquier, C. Auclair, L. Packer and R. Olivier for having brought together many specialists in an international meeting held in Paris in March 1993, at the Ministry of Research. This book comprises an impressive amount of recent knowledge, a real mine for the reader in this fast developing field of research. Furthermore, we should not forget that this basic research may lead in the future to new therapeutic approaches to the most important pathologies of the latter part of this century, including AIDS.

• AIDS
• Activation
• bacteria
• cell
• immune system
• nucleic acid
• oxidative stress
• pathology
• protein
• proteins
• tissue

• INSERM U. 294, Paris, France

  C. Pasquier

• Dept. SIDA & Rétrovirus, Unité d’Oncologie Virale, Paris, France

  R. Y. Olivier

• Institut Gustave Roussy, INSERM U. 140, Villejuif Cedex, France

  C. Auclair

• Dept. of Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, Berkeley, USA

  Lester Packer

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