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Molecular Oncology and Clinical Applications

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  • © 1993
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Overview

Editors:
  1. A. Cittadini

    1. Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Roma, Italy

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  2. R. Baserga

    1. Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, USA

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  3. H. M. Pinedo

    1. Dept. Oncology, Free University Hospital, Amsterdam, The Netherlands

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  4. T. Galeotti

    1. Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Roma, Italy

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  5. D. Corda

    1. Istituto di Ricerche, Farmacologiche “M. Negri”, S. Maria Imbaro, Italy

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Part of the book series: Molecular and Cell Biology Updates (MCBU)

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Table of contents (49 chapters)

  1. Front Matter

    Pages i-ix
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  2. Molecular aspects of cell transformation and growth

    1. Front Matter

      Pages 1-1
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    2. The Impact of Molecular Genetics on Cancer Research

      • R. Dulbecco
      Pages 3-13
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    3. Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas

      • G. Vecchio, A. Fusco, M. Grieco, M. Santoro, M. T. Berlingieri, M. A. Pierotti et al.
      Pages 15-23
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    4. The Role of Tumor Suppressor Genes in Human Cancer Progression

      • W. K. Cavenee
      Pages 25-36
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    5. The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation

      • R. Baserga, B. A. Jameson, E. Surmacz
      Pages 37-48
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    6. Loss of TGF-ß Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis

      • A. B. Glick, T. Tennenbaum, H. Hennings, S. H. Yuspa
      Pages 49-57
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    7. Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor

      • G. Gaudino, L. Gandino, M. F. Di Renzo, S. Giordano, A. Graziani, L. Naldini et al.
      Pages 59-74
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    8. Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas — Cloning of the Gene Encoding Trop-2

      • S. Alberti, M. Stella, R. Dell’ Arciprete, C. Bucci, A. Naglieri, M. Nutini et al.
      Pages 75-82
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    9. Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma

      • M. Genuardi, P. Tanci, S. Greggi, G. Scambia, R. Cento, G. Neri
      Pages 83-87
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    10. Mg2+ in the Regulation of Ascites Tumor Cell Energy Metabolism

      • D. Bossi, F. I. Wolf, G. Calviello, L. Lauro, G. Curigliano, A. Romito et al.
      Pages 89-94
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    11. Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia

      • G. Elia, M. G. Santoro
      Pages 95-101
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    12. Regulation of MnSOD Expression by Manganese in Tumors

      • S. Borrello, M. E. De Leo, T. Galeotti
      Pages 103-107
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  3. Membrane receptors and signal transduction

    1. Front Matter

      Pages 109-109
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    2. An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes

      • A. M.-L. Chan, S. A. Aaronson
      Pages 111-122
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    3. The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism

      • I. B. Weinstein, S. N. Guadagno, Ch. Borner, A. Cacace, S. Kahn, K. O’Driscoll
      Pages 123-128
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    4. Regulation of Protein Kinase C

      • P. J. Parker, A. Carozzi, L. Dekker, R. S. Ginger, N. Goode, S. Kiley et al.
      Pages 129-136
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    5. Potential Roles of p21ras in Growth Factor Signalling — An Overview

      • C. J. Marshall, L. R. Howe, S. J. Leevers, H. F. Paterson, S. G. Thorneycroft
      Pages 137-139
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    6. p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways

      • C. T. Baldari, A. Heguy, J. L. Telford
      Pages 141-146
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    7. Further Characterization of CDC25Mm, a Mammalian Activator of p21ras

      • E. Sturani, R. Zippel, E. Martegani, M. Vanoni, C. Ferrari, P. Coccetti et al.
      Pages 147-151
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Keywords

About this book

The basic knowledge of cell biology and molecular genetics in oncology is increasingly attracting the interest of clinical oncologists and is close to reaching a helpful application at the bedside. At present, it seems clear that the solution of the cancer problem lies within the comprehension of the intimate mechanisms leading to cell transformation and tumor progression as weIl as of the cancer-host relationship. According to this rationale every achievement in this context could drastically improve both diagnosis and therapy of neoplastic diseases. This={)ook represents the proceedings of the International Conference o~ Cancer: Biological Mechanisms and Clinical Applications, held in Rome on November 16-18, 1992. The meeting was organized by the Centro di Ricerche Oncologiche "Giovanni XXIII" of the Catholic University of Rome and the Consorzio Mario Negri Sud of S. M. Imbaro in collaboration with other colleagues from the Universities of Napoli and Bologna. As organizers and pmticipants to the Conference we think the meeting was a success, as was confirmed by the great interest raised in scientific and academic circles. The book collects contributions from leading scientists in all oncological m·eas ranging from molecular biology to immunology, diagnosis and therapy. The papers are organized into four sections: I - Molecular aspects of cell transformation and growth; II - Membrane receptors and signal transduction; III - Models for new therapeutical strategies; IV - Clinical Applications, following the strategy that chm·acterized the entire meeting: from molecule to bedside.

Editors and Affiliations

  • Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Roma, Italy

    A. Cittadini, T. Galeotti

  • Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, USA

    R. Baserga

  • Dept. Oncology, Free University Hospital, Amsterdam, The Netherlands

    H. M. Pinedo

  • Istituto di Ricerche, Farmacologiche “M. Negri”, S. Maria Imbaro, Italy

    D. Corda

Bibliographic Information

  • Book Title: Molecular Oncology and Clinical Applications

  • Editors: A. Cittadini, R. Baserga, H. M. Pinedo, T. Galeotti, D. Corda

  • Series Title: Molecular and Cell Biology Updates

  • DOI: https://doi.org/10.1007/978-3-0348-5663-8

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 1993

  • Softcover ISBN: 978-3-0348-5665-2Published: 23 August 2014

  • eBook ISBN: 978-3-0348-5663-8Published: 21 November 2013

  • Edition Number: 1

  • Number of Pages: IX, 437

  • Number of Illustrations: 73 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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