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  • © 2021

Applying Quantitative Bias Analysis to Epidemiologic Data

  • Employs theory and skills to illustrate epidemiologic biases through a quantitative lens
  • Features step-by-step examples for every method
  • Includes guidance on best practices for bias analysis

Part of the book series: Statistics for Biology and Health (SBH)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xvi
  2. Introduction, Objectives, and an Alternative

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 1-24
  3. A Guide to Implementing Quantitative Bias Analysis

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 25-55
  4. Data Sources for Bias Analysis

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 57-73
  5. Selection Bias

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 75-103
  6. Uncontrolled Confounders

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 105-139
  7. Misclassification

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 141-195
  8. Preparing for Probabilistic Bias Analysis

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 197-231
  9. Probabilistic Bias Analysis for Simulation of Summary Level Data

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 233-290
  10. Probabilistic Bias Analysis for Simulation of Record-Level Data

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 291-327
  11. Direct Bias Modeling and Missing Data Methods for Bias Analysis

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 329-368
  12. Bias Analysis Using Bayesian Methods

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 369-413
  13. Multiple Bias Modeling

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 415-440
  14. Best Practices for Quantitative Bias Analysis

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 441-452
  15. Presentation and Inference

    • Matthew P. Fox, Richard F. MacLehose, Timothy L. Lash
    Pages 453-462
  16. Back Matter

    Pages 463-467

About this book

This textbook and guide focuses on methodologies for bias analysis in epidemiology and public health, not only providing updates to the first edition but also further developing methods and adding new advanced methods.

As computational power available to analysts has improved and epidemiologic problems have become more advanced, missing data, Bayes, and empirical methods have become more commonly used. This new edition features updated examples throughout and adds coverage addressing:

  • Measurement error pertaining to continuous and polytomous variables
  • Methods surrounding person-time (rate) data
  • Bias analysis using missing data, empirical (likelihood), and Bayes methods

A unique feature of this revision is its section on best practices for implementing, presenting, and interpreting bias analyses. Pedagogically, the text guides students and professionals through the planning stages of bias analysis, including the design of validation studies and the collection of validity data from other sources. Three chapters present methods for corrections to address selection bias, uncontrolled confounding, and measurement errors, and subsequent sections extend these methods to probabilistic bias analysis, missing data methods, likelihood-based approaches, Bayesian methods, and best practices.


Authors and Affiliations

  • Department of Epidemiology, Boston University School of Public Health, Boston, USA

    Matthew P. Fox

  • Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, USA

    Richard F. MacLehose

  • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, USA

    Timothy L. Lash

About the authors

Timothy Lash, D.Sc., M.P.H., is professor in the Department of Epidemiology at the Rollins School of Public Health and honorary professor of cancer epidemiology in the Department of Clinical Epidemiology at Aarhus University in Aarhus, Denmark. Dr. Lash is also past-President of the Society for Epidemiologic Research (SER) for the 2014-2015 term. His research focuses on predictors of cancer recurrence, including molecular predictors of treatment effectiveness and late recurrence, and he also researches methods and applications of quantitative bias analysis. 

Matthew Fox, D.Sc., M.P.H, is associate professor in the Center for Global Health & Development and in the Department of Epidemiology at Boston University. Before joining Boston University, he was a Peace Corps volunteer in the former Soviet Republic of Turkmenistan. Dr. Fox is currently funded through a K award from the National Institutes of Allergy and Infectious Diseases to work on ways to improve retention in HIV-care programs in South Africa from time of testing HIV-positive through long-term treatment. His research interests include treatment outcomes in HIV-treatment programs, infectious disease epidemiology, and epidemiological methods, including quantitative bias analysis.

Richard MacLehose, Ph.D., is associate professor in the Division of Epidemiology and Community Health at the University of Minnesota. Dr. MacLehose received his M.S. in epidemiology from the University of Washington and his Ph.D. in epidemiology from the University of North Carolina. His research interests include Bayesian statistics (including bias analysis), epidemiologic methods, applied biostatistics, and reproductive and environmental health.



Bibliographic Information

Buy it now

Buying options

eBook USD 44.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 64.79
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 79.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access