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Principles of Electrical Neural Interfacing

A Quantitative Approach to Cellular Recording and Stimulation

  • Textbook
  • © 2022

Overview

Authors:
  1. Liang Guo

    1. The Ohio State University, Columbus, USA

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  • Offers textbook coverage of the neuroelectrophysiological approaches prevalently used in neuroscience research and neuroprosthetics, including the most significant and exciting developments over the past decade
  • Provides sufficient breadth and depth in a logical and stepwise manner
  • Employs equivalent electrical circuit modeling and signal analysis to derive analytical solutions
  • Offers clear and complete mechanistic insights to the underlying biophysics and functioning principles
  • Provides sound interpretations of the resulting signals and phenomena
  • Informs the proper usage and development of this class of important tools

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xx
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  2. Introduction

    • Liang Guo
    Pages 1-6

  3. Properties and Models of Neurons and Electrodes

    1. Front Matter

      Pages 7-7
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    2. Equivalent Circuit Models of Neurons

      • Liang Guo
      Pages 9-15

    3. Recording Electrodes

      • Liang Guo
      Pages 17-31

    4. Stimulating Electrodes

      • Liang Guo
      Pages 33-44

  4. Principles of Electrical Neural Recording

    1. Front Matter

      Pages 45-45
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    2. Intracellular Recording

      • Liang Guo
      Pages 47-56

    3. Extracellular Recording

      • Liang Guo
      Pages 57-70

    4. Extracellular Recording of Propagating Action Potentials

      • Liang Guo
      Pages 71-74

    5. Recording Using Field-Effect Transistors

      • Liang Guo
      Pages 75-77

    6. Neural Recording Using Nanoprotrusion Electrodes

      • Liang Guo
      Pages 79-92

    7. Recording Using Tetrodes

      • Liang Guo
      Pages 93-102

    8. Intracortical Functional Neural Mapping Using an Integrated 3D Ultra-Density MEA

      • Liang Guo
      Pages 103-121

  5. Principles of Electrical Neural Stimulation

    1. Front Matter

      Pages 123-123
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    2. Neuronal Stimulation

      • Liang Guo
      Pages 125-138

    3. Electrical Stimulation to Promote Neuronal Growth

      • Liang Guo
      Pages 139-150

  6. Applications

    1. Front Matter

      Pages 151-151
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    2. Applications

      • Liang Guo
      Pages 153-163

  7. Back Matter

    Pages 165-169
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Keywords

About this book

This textbook fills a gap to supply students with the fundamental principles and tools they need to perform the quantitative analyses of the neuroelectrophysiological approaches, including both conventional and emerging ones, prevalently used in neuroscience research and neuroprosthetics. The content grows out of a course on Neuroengineering and Neuroprosthetics, which the author has taught already several times. The key problems the author addresses include (1) the universal operating mechanisms of neuroelectrophysiological approaches, (2) proper configuration of each approach, and (3) proper interpretation of the resulting signals. Efforts are made both to extract the universal principles underlying this common class of approaches and discern the unique properties of each individual approach. To address these important problems, equivalent electrical circuit modeling and signal analysis are used to unravel the functioning mechanisms and principles and provide sound interpretations to the associated signals and phenomena. This book aims to derive analytical solutions to these equivalent circuits, which can offer clear and complete mechanistic insights to the underlying biophysics.  

Authors and Affiliations

  • The Ohio State University, Columbus, USA

    Liang Guo

About the author

Dr. Liang Guo is an assistant professor in the Department of Electrical and Computer Engineering at The Ohio State University, Columbus, Ohio, USA. He received the B.E. degree in biomedical engineering from Tsinghua University, Beijing in 2004 and the Ph.D. degree in bioengineering from Georgia Institute of Technology, Atlanta, GA in 2011. Subsequently, he worked as a postdoctoral associate in the Langer Lab at Massachusetts Institute of Technology, Cambridge, MA. He started as an assistant professor of Electrical and Computer Engineering and Neuroscience in September 2013 at The Ohio State University. He has dived into the neuroengineering field since his sophomore year in college and has been passionate to adhere to this field through his Ph.D. and postdoc trainings. His primary research interests are in neural interface engineering and biocircuit engineering as applied to neuroscience and neural prosthetics. He has published over 30 journal papers and obtained five patents. Earlier,he had edited a Springer book Neural Interface Engineering: Linking the Physical World and the Nervous System. Among other honors, he was awarded the Defense Advanced Research Projects Agency (DARPA) Young Faculty Award in 2017, the National Science Foundation (NSF) Faculty Early Career Development (CAREER) Award in 2018, and the OSU College of Engineering Lumley Research Award in 2018.

Bibliographic Information

  • Book Title: Principles of Electrical Neural Interfacing

  • Book Subtitle: A Quantitative Approach to Cellular Recording and Stimulation

  • Authors: Liang Guo

  • DOI: https://doi.org/10.1007/978-3-030-77677-0

  • Publisher: Springer Cham

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-77676-3Published: 30 September 2021

  • Softcover ISBN: 978-3-030-77679-4Published: 01 October 2022

  • eBook ISBN: 978-3-030-77677-0Published: 29 September 2021

  • Edition Number: 1

  • Number of Pages: XX, 169

  • Number of Illustrations: 17 b/w illustrations, 32 illustrations in colour

  • Topics: Biomedical Engineering and Bioengineering, Circuits and Systems, Nanotechnology and Microengineering

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