Overview
- Highlights unique role of satellite DNAs in physiological and evolutionary processes
- Reviews gene-regulatory aspects of satellite DNAs in various model systems
- Examines satellite DNA activation during pathological transformation
Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 60)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (8 chapters)
-
Front Matter
Keywords
About this book
This book gives a comprehensive overview of the unique roles that non-coding repetitive elements such as satellite DNAs play in different physiological and evolutionary processes.
It presents the gene-regulatory aspect of satellite DNAs in different model systems including mammals, insects and plants. In addition, evolutionary aspects of activation of satellite DNAs in terms of transcription and proliferation are highlighted, revealing the role of satellite DNAs in the process of adaptation to changing environment and in the speciation process.
Finally, the book discusses satellite DNA activation during pathological transformation and the mechanisms by which they affect disease progression. Namely, some satellite DNAs promote the oncogenic processes by affecting genome epigenetic regulation as well as genome integrity. Readers get a full overview of the latest research on satellite DNA.
Editors and Affiliations
About the editor
Her major research interest is studying evolution and function of satellite DNA, which is a major DNA component of heterochromatin in many eukaryotes. Using the beetle Tribolium castaneum as a model system, her group demonstrated for the first time the role of satellite DNA in the modulation of gene expression and revealed the molecular mechanism of their gene-regulatory activity. The influence of satellite DNA on neighbouring genes is epigenetic in nature and is induced upon heat stress, suggesting an important role of satellite DNA in the environmental adaptation. Đ. Ugarković predicted the presence of functional elements within satellite DNAs and, together with colleagues at the Ruđer Bošković Institute, provided the first experimental evidence for the existence of a set or a “library” of satellite DNAs shared among related species. This explained a mode of satellite DNA evolution which is based on random amplification from the common “library”.
She is member of the European Molecular Biology Organization (EMBO) since 2000 and associate member of the Croatian Academy of Sciences and Arts.
Bibliographic Information
Book Title: Satellite DNAs in Physiology and Evolution
Editors: Ðurðica Ugarković
Series Title: Progress in Molecular and Subcellular Biology
DOI: https://doi.org/10.1007/978-3-030-74889-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-74888-3Published: 14 August 2021
Softcover ISBN: 978-3-030-74891-3Published: 15 August 2022
eBook ISBN: 978-3-030-74889-0Published: 13 August 2021
Series ISSN: 0079-6484
Series E-ISSN: 2197-8484
Edition Number: 1
Number of Pages: XII, 234
Number of Illustrations: 5 b/w illustrations, 29 illustrations in colour
Topics: Genetics and Genomics, Chemistry/Food Science, general, Biomaterials, Cell Biology