Editors:
Is the first to summarize the past 26 years of research in this field
Provides both mechanistic and translational information regarding anoikis, in a convenient format
Serves as a unique resource for cell-, molecular- and cancer biologists, as well as their students
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Table of contents (10 chapters)
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Front Matter
About this book
Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.
Editors and Affiliations
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WVU Cancer Institute and Department of Biochemistry, West Virginia University, Morgantown, USA
Steven M. Frisch
About the editor
Bibliographic Information
Book Title: Anoikis
Book Subtitle: How the Extracellular Matrix Regulates Life-or-Death Decisions
Editors: Steven M. Frisch
DOI: https://doi.org/10.1007/978-3-030-73856-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-73854-9Published: 28 July 2021
eBook ISBN: 978-3-030-73856-3Published: 27 July 2021
Edition Number: 1
Number of Pages: VIII, 202
Number of Illustrations: 6 b/w illustrations
Topics: Cancer Research, Apoptosis