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Anoikis

How the Extracellular Matrix Regulates Life-or-Death Decisions

  • Book
  • © 2021

Overview

Editors:
  1. Steven M. Frisch

    1. WVU Cancer Institute and Department of Biochemistry, West Virginia University, Morgantown, USA

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  • Is the first to summarize the past 26 years of research in this field

  • Provides both mechanistic and translational information regarding anoikis, in a convenient format

  • Serves as a unique resource for cell-, molecular- and cancer biologists, as well as their students

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
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  2. Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination

    • Austin Boese, Sumin Kang
    Pages 1-16

  3. Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer

    • Ananthalakshmy Sundararaman, Manipa Saha, Saurav Kumar, Annapoorni Rangarajan
    Pages 17-50

  4. The Intersection of Anoikis Resistance and Fatty Acid Metabolism in Cancer

    • Jaidev Bapat, Benjamin G. Bitler
    Pages 51-68

  5. Shc and the Control of Small GTPase Dynamics in Cellular Anchorage

    • Lance S. Terada
    Pages 69-94

  6. Anoikis and the Human Gut Epithelium in Health and Disease

    • Marco Beauséjour, Ariane Boutin, Pierre H. Vachon
    Pages 95-126

  7. The Roles of Anoikis in Cervical Cancer

    • Yang Li, Shanshan Yang, Wei Hu, Anil K. Sood
    Pages 127-136

  8. Anoikis Resistance in Melanoma

    • Jacinta L. Simmons, Mei Fong Ng, Hannah M. Neuendorf, Glen M. Boyle
    Pages 137-160

  9. Anoikis Mediated by Stress-Activated MAPK Signaling Pathways

    • Nomeda Girnius, Roger J. Davis
    Pages 161-172

  10. The TGFβ and Androgen Receptor Signaling Pathways Converge to Support Anoikis Resistance in Triple Negative Breast Cancer

    • Emmanuel Rosas, Jennifer Richer
    Pages 173-192

  11. Regulation of Homeostasis and Anoikis by Epithelial Cell Extrusion

    • Steven M. Frisch
    Pages 193-202
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Keywords

About this book

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions.  Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant.  In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis.  While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized.  The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment;  c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment;  e. regulation by EMT.

Editors and Affiliations

  • WVU Cancer Institute and Department of Biochemistry, West Virginia University, Morgantown, USA

    Steven M. Frisch

About the editor

Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.

Bibliographic Information

  • Book Title: Anoikis

  • Book Subtitle: How the Extracellular Matrix Regulates Life-or-Death Decisions

  • Editors: Steven M. Frisch

  • DOI: https://doi.org/10.1007/978-3-030-73856-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-73854-9Published: 28 July 2021

  • eBook ISBN: 978-3-030-73856-3Published: 27 July 2021

  • Edition Number: 1

  • Number of Pages: VIII, 202

  • Number of Illustrations: 6 b/w illustrations

  • Topics: Cancer Research, Apoptosis

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