Overview
- Provides insight into the clinical and translational application of natural products in human diseases
- Details the impact of natural products on a molecular basis
- Describes the identification of biomarkers, therapeutic effects of phytochemicals, and and new targets
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1328)
Part of the book sub series: Proteomics, Metabolomics, Interactomics and Systems Biology (PMISB)
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Table of contents (39 chapters)
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Front Matter
Keywords
About this book
Natural products have a long history of use as folk medicines in several systems of traditional medicine. Extensive evidence from modern pharmacological studies has confirmed traditional applications, and unveiled the vast potential of naturally occurring compounds, particularly plant-derived phytochemicals, in the management of chronic human diseases. The past decade has witnessed a surge of findings from randomized controlled trials testifying the safety and efficacy of natural products as adjuncts or alternatives to standard-of-care medications for several illnesses. Biomolecular studies have unveiled hundreds of cellular and molecular targets for phytochemicals including key transcription factors, receptors, enzymes, hormones, neurotransmitters, cytokines, lipids, and non-coding RNAs.
Extensive research on the preventative and therapeutic effects of natural products necessitates regular updating of the literature as to the developing potential roles of these compounds in different human diseases. This new book provides an overview of the current pharmacological and clinical features of natural products, and the role of phytopharmaceutical compounds in health and diseases. Chapters cover a wide scope, from cancers, to chronic and age-related disorders, and are written by leading international subject experts. Collectively, chapters will provide useful insights on the regulatory effects of phytochemicals and nutraceuticals on pathogenic molecular signatures associated with pathologies, disease biomarkers, and aging-related pathways.
Editors and Affiliations
About the editors
Amirhossein Sahebkar, PharmD., PhD., is Associate Professor of Pharmaceutical Biotechnology in the School of Pharmacy at the Mashhad University of Medical Sciences in Iran, and Honorary Research Fellow in the School of Health and Medical Sciences at the University of Western Australia. He has published more than 1100 articles on areas including blood lipids, neurovascular diseases, modern medical treatments in cellular, molecular, and animal tissues, and atherosclerosis. He is a highly cited researcher in the field of Pharmacology and Toxicology and has an h-index of 85.
Thozhukat Sathyapalan, MD., FRCP., FACP., is the Chair in Academic Diabetes, Endocrinology and Metabolism in Hull York Medical School, University of Hull and Honorary Consultant Endocrinologist at Hull and East Yorkshire Hospitals NHS Trust, United Kingdom. His main area of interest is on modulation of cardiometabolic risk through pharmacological and nutritional interventions. He hasconducted several clinical trials in this area. He has also published and presented extensively in this field.
Bibliographic Information
Book Title: Natural Products and Human Diseases
Book Subtitle: Pharmacology, Molecular Targets, and Therapeutic Benefits
Editors: Amirhossein Sahebkar, Thozhukat Sathyapalan
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-73234-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-73233-2Published: 05 January 2022
eBook ISBN: 978-3-030-73234-9Published: 03 January 2022
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XI, 556
Number of Illustrations: 21 b/w illustrations, 59 illustrations in colour
Topics: Organic Chemistry, Biochemistry, general, Pharmacology/Toxicology, Biomedicine, general