Precision Medicine in Stroke

1. Front Matter

   Pages i-viii

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2. Precision Medicine

   1. Front Matter

      Pages 1-1

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   2. Introduction

      • José M. Ferro

      Pages 3-7

   3. Precision Medicine: Enabling Healthcare Progress in the Twenty-First Century

      • Maria Carmo-Fonseca

      Pages 9-19

   4. Do We Need Precision Medicine in Stroke?

      • Ana Catarina Fonseca

      Pages 21-26

3. Current Applications of Precision Medicine in Ischemic Stroke

   1. Front Matter

      Pages 27-27

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   2. Monogenic Stroke Diseases

      • Elisabeth Tournier-Lasserve

      Pages 29-40

   3. Pharmacodynamics and Pharmacokinetics of Stroke Therapy

      • Miguel Leal Rato, Maria José Diógenes, Ana Sebastião

      Pages 41-69

   4. Current Applications of Precision Medicine in Stroke: Acute Stroke Imaging

      • Luisa Biscoito

      Pages 71-123

4. Current Applications of Precision Medicine in Haemorrhagic Stroke

   1. Front Matter

      Pages 125-125

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   2. Intracerebral Haemorrhage

      • Jonathan G. Best, David J. Werring

      Pages 127-159

5. Future Application

   1. Front Matter

      Pages 161-161

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   2. Blood Biomarkers in the Diagnosis of Acute Stroke

      • Gian Marco De Marchis, Tolga D. Dittrich

      Pages 163-189

   3. Future Application: Prognosis Determination

      • Svetlana Lorenzano

      Pages 191-258

6. Interdisciplinary Approach

   1. Front Matter

      Pages 259-259

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   2. Artificial Intelligence Applications in Stroke

      • Arlindo L. Oliveira

      Pages 261-273

   3. Registry-Based Stroke Research

      • Niaz Ahmed, Tiago Prazeres Moreira

      Pages 275-288

   4. From Bedside to Bench: Methods in Precision Medicine

      • Filipe Cortes-Figueiredo, Vanessa A. Morais, Helena Pinheiro

      Pages 289-307

   5. Approach for Genetic Studies

      • Gie Ken-Dror, Pankaj Sharma

      Pages 309-327

7. Conclusion

   1. Front Matter

      Pages 329-329

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This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area.

Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.

• cerebrovascular disease
• genetics
• artificial intelligence
• acute stroke imaging
• ischemic stroke
• pharmacogenetics

• Neurology, University of Lisbon, Lisbon, Portugal

  Ana Catarina Fonseca

• Department of Neurosciences, University of Lisbon, Lisbon, Portugal

  José M. Ferro

Ana Catarina Fonseca has a PhD in Medicine, from the Faculty of Medicine, University of Lisbon (2014), within the medical specialty of neurology. In 2014 she completed a Masters in Public Health from Harvard University (USA), having previously completed two masters: in Stroke Medicine at the University Danube Krems (Austria) and in Neuroscience at the University of Lisbon. She is a researcher at the Institute of Molecular Medicine, teaches Pharmacology and Neurology at the Faculty of Medicine - University of Lisbon and practices medicine at the Hospital de Santa Maria in Lisbon. Her main research interests are cryptogenic stroke, heart-brain interactions and biomarkers. She is currently working in a research project in precision medicine in stroke entitled PRECISE-STROKE with the collaboration of informatics engineers, physicians and basic scientists.

José M. Ferro was born in Lisbon on 22 October 1951. He graduated in 1975 and received his PhD in Medicine in 1987 from the University of Lisbon. He was a post-doctoral fellow at the Department of Clinical Neurological Sciences,London, Canada. He is currently Full Professor of Neurology and President of the “Conselho de Escola” of the School of Medicine at the University of Lisbon. He is Director of the Department of Neurosciences and Mental Health and Director of the Neurology Service at the Hospital de Santa Maria, Centro Hospitalar Lisboa Norte. He is the head of José Ferro Lab at the Instituto de Medicina Molecular, University of Lisbon. He was President of the European Neurological Society. He has authored or co-authored 309 papers published in international journals and 60 book chapters. His main area of research interest is cerebrovascular disease, with a focus on cerebral venous thrombosis, cryptogenic stroke and cognitive and psychiatric consequences of stroke. He is currently principal investigator of a research project regarding precision medicine in stroke – PRECISE-STROKE.

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