Overview
- Reviews proteinkinase inhibitors
- Exploits kinase inhibitors for cancer treatment
- Offers an authoritative perspective from industry and academia
Part of the book series: Topics in Medicinal Chemistry (TMC, volume 36)
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Table of contents (8 chapters)
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Front Matter
Keywords
About this book
This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.
Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Proteinkinase Inhibitors
Editors: Stefan Laufer
Series Title: Topics in Medicinal Chemistry
DOI: https://doi.org/10.1007/978-3-030-68180-7
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-68179-1Published: 24 March 2021
Softcover ISBN: 978-3-030-68182-1Published: 24 March 2022
eBook ISBN: 978-3-030-68180-7Published: 23 March 2021
Series ISSN: 1862-2461
Series E-ISSN: 1862-247X
Edition Number: 1
Number of Pages: VII, 256
Number of Illustrations: 1 b/w illustrations
Topics: Medicinal Chemistry, Protein Science, Bioorganic Chemistry, Pharmaceutical Sciences/Technology