Imaging Dementia

1. Front Matter

   Pages i-xvi

   PDF

2. Alzheimer’s Disease

   • Massimo Filippi, Federica Agosta

   Pages 1-30

3. Vascular Cognitive Impairment

   • Massimo Filippi, Federica Agosta

   Pages 31-59

4. Frontotemporal Lobar Degeneration

   • Massimo Filippi, Federica Agosta

   Pages 61-89

5. Parkinsonian Dementias

   • Massimo Filippi, Federica Agosta

   Pages 91-117

6. Rapidly Progressive Dementias

   • Massimo Filippi, Federica Agosta

   Pages 119-138

This book helps physicians select from among the currently available imaging tools, promoting the correct and cost-saving diagnosis and management of common dementias. Magnetic resonance (MR) and nuclear medicine techniques are routinely used to facilitate diagnosis, select therapies, provide information regarding the prognosis, and monitor therapy response in patients with cognitive impairment and dementia. Furthermore, the advent of quantitative MR techniques, such as diffusion-weighted imaging, perfusion imaging, etc. have opened up new opportunities to diagnose neurological diseases based on objective findings, and offer unique new insights into the main neurodegenerative diseases of the human brain. However, the practical value of various neuroimaging techniques in clinical practice has yet to be clearly defined, and their potential for future development is not yet fully appreciated.

To help remedy the situation, this book offers practical and useful algorithms and rulesthat can be directly applied in the clinical setting. It provides concise content, together with a wealth of clinical case material.

• Cognitive impairment
• Alzheimer’s disease
• Vascular dementia
• Early onset dementia
• Parkinsonisms
• Rapidly progressive dementia
• Magnetic resonance imaging
• Positron emission tomography

“The presence of tables/ flow diagrams and explanation of radiological interpretation with glossy pictures with sharp definition are most invaluable … . this book is a well researched, informative read and recommended to radiologists just starting out or looking for a refresher/update on reporting imaging for suspected primary dementia. Clinical neurologist physicians and general physicians with interest in geriatrics may also find the book useful, particularly given the wealth of clinicopathology information and guidance on the variety of imaging available.” (Aimee Lawson, RAD Magazine, October, 2021)

• Neuroimaging Research Unit, Division of Neuroscience, Neurology Unit, Neurorehabilitation Unit, Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

  Massimo Filippi

• Neuroimaging Research Unit, Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

  Federica Agosta

Massimo Filippi is currently: Full Professor of Neurology at Vita-Salute San Raffaele University, Milan, Italy; Director of the Residency School in Neurology, and President of the Bacherlor’s Degree in Physiotherapy at the same University; Chair of the Neurology Unit, Director of the MS Center, Director of the Neurophysiology Unit, and Director of the Neuroimaging Research Unit (NRU) at IRCCS Scientific Institute San Raffaele, Milan. His research activity has always focused on the definition of the mechanisms leading to progressive accumulation of irreversible physical disability and cognitive impairment in various neurological conditions. He is member of various national and international Scientific Societies and Boards where he covered or is covering institutional roles. He is author of over 1150 papers, Editor-in-Chief of the Journal of Neurology and member of the Editorial Boards of many international scientific journals. He is very often requested as speaker and/or chairman in national and international neurological congresses. In 2001, Prof. Filippi was awarded the Rita Levi Montalcini Prize for his outstanding contributions to the study of MS.

Federica Agosta is a Group Leader at the Division of Neuroscience, IRCCS Ospedale San Raffaele (OSR), where she conducts research in patients with neurodegenerative conditions. She has a broad background in clinical neurology and neuroimaging, with specific training and expertise in MRI and neurodegenerative diseases. Her research has led to the publication of over 160 Pubmed-referenced papers.

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