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Colon Cancer Diagnosis and Therapy

Volume 1

  • Book
  • © 2021

Overview

Editors:
  1. Ganji Purnachandra Nagaraju

    1. Department of Hematology and Medical Oncology, Emory University, Atlanta, USA

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  2. Dhananjay Shukla

    1. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India

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  3. Naveen Kumar Vishvakarma

    1. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India

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  • Describes the causes and early diagnostic tools for effective use of current and future therapeutic regimens

  • Focuses on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer

  • Provides in-depth information about existing and potential biomarkers for early diagnosis

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii
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  2. Epidemiology of Colorectal Cancer

    • Begum Dariya, Gayathri Chalikonda, Ganji Purnachandra Nagaraju
    Pages 1-13

  3. Colorectal Cancer: A Model for the Study of Cancer Immunology

    • Pranav Kumar Prabhakar
    Pages 15-30

  4. Impact of Covid-19 Pandemic on Gastrointestinal Cancer Patients: An Emphasis on Colorectal Cancer

    • Krishna Patel, Nuri Hamby, Sohail Siraj, Ananya Kurri, Riyaz Basha
    Pages 31-41

  5. Role of NMR Metabolomics and MR Imaging in Colon Cancer

    • Pradeep Kumar, Virendra Kumar
    Pages 43-66

  6. Role of MicroRNA In Situ Hybridization in Colon Cancer Diagnosis

    • Shalitha Sasi, Sapna Singh, Tamanna Walia, Ramesh Chand Meena, Suresh Thakur
    Pages 67-89

  7. Role of Epigenetics in Colorectal Cancer

    • Beiping Miao, Sonal Gupta, Manisha Mathur, Prashanth Suravajhala, Obul Reddy Bandapalli
    Pages 91-99

  8. Exosomal Biomarkers in Colorectal Cancer

    • S. Priya, P. K. Satheeshkumar
    Pages 101-122

  9. Biomarkers as Putative Therapeutic Targets in Colorectal Cancer

    • Sonali Pal, Manoj Garg, Amit Kumar Pandey
    Pages 123-177

  10. Proteins Involved in Colorectal Cancer: Identification Strategies and Possible Roles

    • Sudhir Kumar, Divya Goel, Neeraj, Vineet Kumar Maurya
    Pages 179-194

  11. Short-Chain Fatty Acids as Therapeutic Agents in Colon Malignancies

    • Arundhati Mehta, Vivek Kumar Soni, Yashwant Kumar Ratre, Rajat Pratap Singh, Dhananjay Shukla, Naveen Kumar Vishvakarma et al.
    Pages 195-218

  12. Targeting Angiogenesis for Colorectal Cancer Therapy

    • Vaishali Gupta, Taha Bharmal, Vineeta Dixit, Naveen Kumar Vishvakarma, Atul Kumar Tiwari, Dhananjay Shukla et al.
    Pages 219-238

  13. Anti-Inflammatory Molecular Mechanism and Contribution of Drug Transport Molecules in Colorectal Cancer Cells

    • Dowluru S. V. G. K. Kaladhar, Srinivasan Tantravahi
    Pages 239-255

  14. Emerging Role of Circulating Tumour DNA in Treatment Response Prognosis in Colon Cancer

    • Eveline M. Anto, Anaga Nair, Jayamurthy Purushothaman
    Pages 257-270

  15. Immuno-modulating Mediators of Colon Cancer as Immuno-therapeutic: Mechanism and Potential

    • Chanchal Kumar, Rajat Pratap Singh, Mrigendra Kumar Dwiwedi, Ajay Amit
    Pages 271-308

  16. Immune Checkpoint Inhibitors as an Armor for Targeted Immunotherapy of Colorectal Cancer

    • Smita Kapoor, Yogendra S. Padwad
    Pages 309-326

  17. Examining the Role of the MACC1 Gene in Colorectal Cancer Metastasis

    • Aparna S. Narayan, Jayshree Nellore, Valli C. Nachiyar, Sujatha Peela
    Pages 327-352

  18. Back Matter

    Pages 353-369
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Keywords

About this book

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis.


This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Editors and Affiliations

  • Department of Hematology and Medical Oncology, Emory University, Atlanta, USA

    Ganji Purnachandra Nagaraju

  • Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India

    Dhananjay Shukla, Naveen Kumar Vishvakarma

About the editors

Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Nagaraju obtained his MSc and PhD, both in Biotechnology from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. Dr. Nagaraju received his D.Sc. from Berhampur University in Berhampur, Odisha, India. Nagaraju's research focuses on translational research in gastrointestinal malignancies. He has published over 100 research papers in highly respected international journals and has presented more than 50 abstracts at various national and international conferences. He is the author and editor of several books. Dr. Nagaraju is an editorial board member of several internationally recognized academic journals, and is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He is a member of the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, The RNA Society and the American Association of Cancer Research (AACR).


Dr. Dhananjay Shukla is an Assistant Professor in the Department of Biotechnology at Guru Ghasidas Vishwavidyalaya (A Central University) in India. Dr. Shukla received his PhD in Biotechnology from Defense Institute of Physiology and Allied Science, New Delhi, India. Dr. Shukla has expertise in cancer physiology and has published more than 25 research papers in various highly reputed international journal. He has presented and been invited to lecture at a number national and international conferences.


Dr. Naveen Kumar Vishvakarma is an Assistant Professor in the Department of Biotechnology at Guru Ghasidas Vishwavidyalaya (A Central University) in India. Dr. Vishvakarma received his PhD in Biotechnology from Banaras Hindu University, Varanasi, India. He has published more than 20 research papers in highly reputed journals on various aspects of cancer biology. He has written a number of book chapters for international publishers and presented abstract at national and international conferences.

Bibliographic Information

  • Book Title: Colon Cancer Diagnosis and Therapy

  • Book Subtitle: Volume 1

  • Editors: Ganji Purnachandra Nagaraju, Dhananjay Shukla, Naveen Kumar Vishvakarma

  • DOI: https://doi.org/10.1007/978-3-030-63369-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-63368-4Published: 11 June 2021

  • eBook ISBN: 978-3-030-63369-1Published: 10 June 2021

  • Edition Number: 1

  • Number of Pages: XII, 369

  • Number of Illustrations: 20 illustrations in colour

  • Topics: Cancer Research, Immunology, Biomedicine, general

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