Overview
- Explains limitations of animal tissue models and stresses the need of performing research on human tissue samples
- A valuable reference for setting up organotypic models in the lab
- Provides a general and technical overview of human tissue research
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 430)
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Table of contents (12 chapters)
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Front Matter
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Three Dimensional Human Organotypic Models for Studying Infectious Diseases
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Front Matter
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Three Dimensional Human Organotypic Models for Studying Non-infectious Diseases
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Front Matter
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Keywords
About this book
This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives.
This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab.
Chapters 'Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers' and 'Human Organotypic Models for Anti-infective Research' of this book are available open access under a CC BY 4.0 license at link.springer.com.
Editors and Affiliations
About the editors
Rino Rappuoli is Chief Scientist and Head External R&D at GSK Vaccines, based in Siena, Italy and Professor of Vaccinology at Imperial College, London. Prior positions: head of Vaccine R&D at Novartis, CSO of Chiron Corporation, head for R&D at Sclavo.
He earned his PhD in Biological Sciences at the University of Siena, Italy, and was visiting scientist at Rockefeller University and Harvard Medical School.
He is elected member of US National Academy of Sciences (NAS), the European Molecular Biology Organization (EMBO), and the Royal Society of London. Awards received: Gold Medal by the Italian President, Albert B Sabin Gold Medal, Canada Gairdner International Award, European Inventor Award for Lifetime Achievement, and Robert Koch Award. He was nominated third most influential person worldwide in the field of vaccines (Terrapin). He has published more than 700 works in peer-reviewed journals.
He introduced novel scientific concepts: genetic detoxification; cellular microbiology; reverse vaccinology; pangenome. Developed licensed vaccines: acellular pertussis containing a non-toxic mutant of pertussis toxin; first conjugate vaccine against meningococcus C; MF59, the first vaccine adjuvant after aluminium salts; meningococcus B; CRM 197 used as carrier in many conjugate vaccines.
Dr. Rappuoli is among theworld scientific leaders dedicated to the sustainability of global health.Bibliographic Information
Book Title: Three Dimensional Human Organotypic Models for Biomedical Research
Editors: Fabio Bagnoli, Rino Rappuoli
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-030-62452-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-62451-4Published: 21 May 2021
Softcover ISBN: 978-3-030-62454-5Published: 22 May 2022
eBook ISBN: 978-3-030-62452-1Published: 20 May 2021
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VIII, 265
Number of Illustrations: 2 b/w illustrations, 20 illustrations in colour
Topics: Immunology, Cancer Research, Regenerative Medicine/Tissue Engineering, Stem Cells, Cell Culture