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The Human Hypothalamus

Anatomy, Dysfunction and Disease Management

  • Book
  • © 2021

Overview

Editors:
  1. Gabriel I. Uwaifo

    1. Department of Endocrinology, Diabetes, Metabolism and Weight Management, Ochsner Medical Center, New Orleans, USA

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  • Presents a comprehensive, up-to-date description of the anatomy, function, dysfunction, and diseases of the hypothalamus, including clinical management
  • Discusses hormone excess and deficiency, obesity and wasting, sleep disorders, tumors and mass lesions, ROHHAD, and idiopathic and iatrogenic diseases of the hypothalamus, among other topics
  • An excellent resource for endocrinologists, neurologists, neurosurgeons, psychiatrists, residents and fellows in these areas

Part of the book series: Contemporary Endocrinology (COE)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Structure and Function of the Hypothalamus

    1. Front Matter

      Pages 1-1
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    2. Introduction to the Hypothalamus: Correlates From Animal Studies

      • Miana-Gabriela Pop, Carmen Bianca Crivii, Iulian Opincariu
      Pages 3-6

    3. Anatomy and Topography of the Hypothalamus

      • Carmen Bianca Crivii, Simona Valeria Clichici, Adriana Gabriela Filip
      Pages 7-14

    4. Neuroimaging of the Human Hypothalamus

      • Rashmi S. Thakkar, Frank Berkowitz
      Pages 15-32

    5. Neurophysiology of the Hypothalamus

      • Stefany D. Primeaux, Lisa M. Harrison-Bernard, Maria J. Barnes
      Pages 33-52

    6. Neuroendocrinology of the Hypothalamus and Pituitary Axes

      • Trung Nam Tran, Max Sosa Pagan, Gabriel I. Uwaifo
      Pages 53-122

  3. Pathobiology and Dysfunction of the Hypothalamus

    1. Front Matter

      Pages 123-123
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    2. Imaging Aspects of Pathologies of the Sella, the Pituitary Gland, and the Hypothalamus

      • Manuel Schmidt, Arnd Doerfler
      Pages 125-140

    3. Neurological Syndromes of the Hypothalamus

      • Christopher Morgan Smith, Rima El-Abassi, David Chachkhiani
      Pages 141-155

    4. Neuropsychiatric and Neurobehavioral Syndromes of the Human Hypothalamus

      • John Wagner III, Noeen Sarfraz, Kunal Maini, Amber N. Edinoff
      Pages 157-170

    5. Neurosurgical Aspects of Hypothalamic Disease

      • Ketan R. Bulsara, Joshua Knopf, Rebecca Calafiore, Anzhela D. Moskalik
      Pages 171-180

    6. Hormone Excess Syndromes of the Hypothalamic-Pituitary Axis

      • Nidhi Agrawal, Hyon Kim, Kyla Wright, Sonal Mehta
      Pages 181-213

    7. Hormone Deficiency Syndromes of the Hypothalamic-Pituitary Axis

      • Shruti Polu, Juan C. Sarmiento-Ramon, Nyrene A. Haque, Susan L. Karam
      Pages 215-233

    8. Hypothalamic Obesity and Wasting Syndromes

      • Gabriel I. Uwaifo
      Pages 235-280

    9. Hypothalamic Sleep Disorders

      • Gloria E. Hoffman, Michael Koban
      Pages 281-291

    10. Genetic Syndromes of Hypothalamic Dysfunction

      • George William Moll Jr, Vishnu Garla
      Pages 293-343

    11. Neuroendocrine Neoplasms and Lesions of the Hypothalamus

      • Ehsan Dowlati, Jordan Black, Amjad N. Anaizi
      Pages 345-365

    12. Non-endocrine Neoplasms of the Hypothalamus

      • Ketan R. Bulsara, Anzhela D. Moskalik, Joshua Knopf, Rebecca Calafiore
      Pages 367-386

    13. Nonneoplastic Mass Lesions of the Hypothalamus

      • Ketan R. Bulsara, Anzhela D. Moskalik, Joshua Knopf, Rebecca Calafiore
      Pages 387-404
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Keywords

About this book

The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus represents the intersection of several areas of clinical and medical expertise. The human hypothalamus can be astutely referred to as the crossroad of endocrinology, psychiatry, neurology and neurosurgery. Because of its involvement in myriad physiologic functions and the varied ways disorders involving it can manifest, hypothalamic disease can initially come to medical attention in widely disparate settings and with widely different clinicians. Therefore, the detection and proper care of hypothalamic dysfunction and disease often requires carefully coordinated multidisciplinary care.


This volume fills a significant void in the medical professional community, comprehensively presenting the scope of hypothalamic structure, function, dysfunction and disease to cater to the various clinical, teaching and researchprofessionals that have a stake in this part of the human brain. This text captures in one place all the information that practicing clinicians, clinician scientists, and researchers need to be adequately informed about various aspects of the hypothalamus in all its complexity. It is comprehensive and broad in scope so that it provides relevant reference information for the wide range of professionals involved in the pre- and post-mortem detection, diagnosis, characterization, care and management of various hypothalamic disorders and diseases in addition to providing a sound anatomic and physiologic foundation of the normal human hypothalamus.
 
The Human Hypothalamus can be used to differing degrees by medical professionals and students alike, finding utility for interested general clinicians, medical school and allied health professional teaching faculty as well as subspecialists in domains as wide as neurosurgery, neuroendocrinology, clinical psychiatry and neuro-oncology.

Reviews

“There are many books that discuss various neuroendocrine disorders; however, this book is one of a kind in highlighting the important role the hypothalamus plays in each of these disorders.” (Amna Elahi, Doody's Book Reviews, January 7, 2022)

Editors and Affiliations

  • Department of Endocrinology, Diabetes, Metabolism and Weight Management, Ochsner Medical Center, New Orleans, USA

    Gabriel I. Uwaifo

About the editor

Gabriel Uwaifo, MD, FACE, FTOS, DABOM, FACP, Associate Clinical Professor, University of Queensland Australia, Ochsner Clinical School, Senior Clinical Scientist and Attending Endocrinologist, Department of Endocrinology, Diabetes, Metabolism and Weight Management, Ochsner Medical Center, New Orleans, LA, USA

Bibliographic Information

  • Book Title: The Human Hypothalamus

  • Book Subtitle: Anatomy, Dysfunction and Disease Management

  • Editors: Gabriel I. Uwaifo

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-3-030-62187-2

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-62186-5Published: 25 December 2020

  • Softcover ISBN: 978-3-030-62189-6Published: 26 December 2021

  • eBook ISBN: 978-3-030-62187-2Published: 24 December 2020

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: XXII, 528

  • Number of Illustrations: 40 b/w illustrations, 69 illustrations in colour

  • Topics: Endocrinology, Neurology

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