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Sex Differences in Heart Disease

  • Book
  • © 2020

Overview

Editors:
  1. Bohuslav Ostadal

    1. Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

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  2. Naranjan S. Dhalla

    1. St. Boniface Hospital Albrechtsen Research Centre, Institute of Cardiovascular Sciences, Winnipeg, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • Discusses the changes in the molecular and cellular mechanisms of ischemic injury in both male and female hearts
  • Provides state-of-the-knowledge concerning the role of sex hormones and mitochondrial function
  • Provides new and novel information regarding the biochemistry of ischemic heart disease

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 21)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Sex Differences in Cardiac Ischemia

    1. Front Matter

      Pages 1-1
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    2. Gender-Related Differences in the Pathogenesis and Diagnosis of Ischemic Heart Disease

      • Marwan Saad, Michael Megaly, Franco Romeo, Jawahar L. Mehta
      Pages 3-23

    3. Sex Differences in Cardiac Ischemia/Reperfusion Injury

      • Bohuslav Ostadal, Petr Ostadal, Jan Neckar
      Pages 25-37

    4. The Roles of Testosterone in Cardiac Ischemia/Reperfusion Injury

      • Nattayaporn Apaijai, Siriporn C. Chattipakorn, Nipon Chattipakorn
      Pages 39-65

    5. The Influence of Sex and Age on Responses of Isolated Ventricular Myocytes to Simulated Ischemia and Reperfusion

      • David G. Sapp, Susan E. Howlett
      Pages 67-85

    6. Non-atherosclerotic Acute Cardiac Events in Young Women

      • Fabiola B. Sozzi, Marco Schiavone, Marta Belmonte
      Pages 87-107

  3. Sex Differences in Heart Failure

    1. Front Matter

      Pages 109-109
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    2. Sex Differences in Contractile Function in Cardiac Hypertrophy and Heart Failure Subsequent to Volume Overload

      • Paramjit S. Tappia, Anureet K. Shah, Mohamad Nusier, Naranjan S. Dhalla
      Pages 111-127

    3. Sex-Specific Differences of Apoptosis in Heart Failure Due to Volume-Overload

      • Sukhwinder K. Bhullar, Anureet K. Shah, Naranjan S. Dhalla
      Pages 129-145

    4. Sex-Specific Differences in β-Adrenoceptor Signal Transduction in Heart Failure Due to Volume-Overload

      • Naranjan S. Dhalla, Vijayan Elimban, Anureet K. Shah, Mohamad Nusier
      Pages 147-158

    5. Sex and Heart Transplantation

      • Ana Ayesta, Manuel Martínez-Sellés
      Pages 159-175

  4. Sex Differences in Risk Factors

    1. Front Matter

      Pages 177-177
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    2. Sex, Age and Gene Interactions in Cardiometabolic Diseases

      • Pavel Hamet, Candan Hizel, Johanne Tremblay
      Pages 179-190

    3. Sex Differences in Response to Fatty Acids in Cardiovascular Health and Disease

      • Paramjit S. Tappia, Anureet K. Shah
      Pages 191-202

    4. Nutritional Aspect of Sex-Dependent Difference in Heart Disease

      • Anureet K. Shah, Anabela Kim, Carrie Adase
      Pages 203-216

    5. Cardio-Oncology: Preventing Broken Hearts in Women with Breast Cancer

      • Hilary Bews, Cameron Eekhoudt, Sonu Varghese, Davinder S. Jassal
      Pages 217-236

  5. Sex Differences in Cardiac Mitochondria in Heart Disease

    1. Front Matter

      Pages 237-237
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    2. Sex-Related Pathophysiological Differences in Cardiac Mitochondria: Role of Estrogens

      • Natalia Pavón, Francisco Correa-Segura, Elizabeth Lira-Silva, Alfredo Cabrera-Orefice
      Pages 239-256

    3. Cardiac Mitochondria and Ischemia/Reperfusion Injury—Sex Differences

      • Zdenek Drahota, Marketa Hlavackova, Bohuslav Ostadal
      Pages 257-265
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Keywords

About this book

Cardiovascular diseases are the leading cause of mortality in men and women. Unfortunately, women have traditionally been excluded from clinical trials, and female animals have been used less or sex was not reported in basic research studies. Until recently, consideration of both sexes was not required in clinical and preclinical studies focusing on cardiovascular diseases. However, the number of clinical and experimental papers dealing with sex differences and heart disease significantly increases during the last years. This trend is obviously the result of at least two facts: the number of examples of different behavior of the male and female heart under physiological and pathological conditions is steadily increasing and there were controversial reports on the beneficial and adverse effect of hormonal replacement therapy. Detailed molecular and cellular mechanisms of these differences are still unknown but one is clear already today: sex differences are so important that they should be considered by the selection of optimum diagnostic and therapeutic procedures in clinical practice.


The book presents 16 manuscripts on sex differences of heart disease, as developed by several investigators; the volume is organized in four parts. Part I, dealing with sex differences in cardiac ischemic injury, includes 5 chapters on experimental aspects of cardiac ischemia/reperfusion injury, the role of testosterone, and clinical aspects of ischemic heart disease. Part II is devoted to sex differences in heart failure and includes four chapters. Discussion in this part of the book is centered around the sex differences in heart failure due to volume overload. Part III of this volume includes four papers on risk factors of cardiovascular diseases, namely hypertension and obesity, and, finally, three chapters in part IV deal with sex differences of cardiac mitochondria under different pathological conditions. We believe this book will be very useful forcardiovascular scientists, graduate students, postdoctoral fellows and other health professionals.


Editors and Affiliations

  • Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

    Bohuslav Ostadal

  • St. Boniface Hospital Albrechtsen Research Centre, Institute of Cardiovascular Sciences, Winnipeg, Canada

    Naranjan S. Dhalla

Bibliographic Information

  • Book Title: Sex Differences in Heart Disease

  • Editors: Bohuslav Ostadal, Naranjan S. Dhalla

  • Series Title: Advances in Biochemistry in Health and Disease

  • DOI: https://doi.org/10.1007/978-3-030-58677-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-58676-8Published: 16 November 2020

  • Softcover ISBN: 978-3-030-58679-9Published: 16 November 2021

  • eBook ISBN: 978-3-030-58677-5Published: 15 November 2020

  • Series ISSN: 2512-2142

  • Series E-ISSN: 2512-2150

  • Edition Number: 1

  • Number of Pages: XVI, 284

  • Number of Illustrations: 32 b/w illustrations, 15 illustrations in colour

  • Topics: Cardiovascular Biology

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