DNA Nanotechnology

1. Front Matter

   Pages i-ix

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2. Towards active self-assembly through DNA nanotechnology

   • Jinyi Dong, Chao Zhou, Qiangbin Wang

   Pages 1-25

3. Tailoring DNA self-assembly to build hydrogels

   • Jie Chen, Ying Zhu, Huajie Liu, Lihua Wang

   Pages 27-56

4. DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials

   • Xuemei Xu, Pia Winterwerber, David Ng, Yuzhou Wu

   Pages 57-81Open Access

5. Engineering Functional DNA-Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications

   • Dan Zhao, Yuhan Kong, Sisi Zhao, Hang Xing

   Pages 83-124

6. DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions

   • Jinglin Fu, Zhicheng Wang, Xiao Hua Liang, Sung Won Oh, Ezry St. Iago-McRae, Ting Zhang

   Pages 125-155

7. Directional assembly of nanoparticles by DNA shapes: towards designed architectures and functionality

   • Ningning Ma, Brian Minevich, Jiliang Liu, Min Ji, Ye Tian, Oleg Gang

   Pages 157-190

8. Oligonucleotide-Polymer Conjugates: From Molecular Basic to Practical Application

   • Fan Xiao, Zixiang Wei, Maggie Wang, Alexandra Hoff, Ying Bao, Leilei Tian

   Pages 191-233

9. Biotechnological and Therapeutic Applications of Natural Nucleic Acid Structural Motifs

   • Jinwei Duan, Xing Wang, Megan E. Kizer

   Pages 235-266

10. DNA-driven Nanoparticle Assemblies for Biosensing and Bioimaging

    • Yuan Zhao, Lixia Shi, Hua Kuang, Chuanlai Xu

    Pages 267-299

11. Aptamer-functionalized DNA Nanostructures for Biological Applications

    • Xiaoyi Fu, Fangqi Peng, Jungyeon Lee, Qi Yang, Fei Zhang, Mengyi Xiong et al.

    Pages 301-343

12. High-performance biosensing based on autonomous enzyme-free DNA circuits

    • Hong Wang, Huimin Wang, Itamar Willner, Fuan Wang

    Pages 345-376

13. DNA strand displacement reaction: a powerful tool for discriminating single nucleotide variants

    • Weiyang Tang, Weiye Zhong, Yun Tan, Guan A. Wang, Feng Li, Yizhen Liu

    Pages 377-406

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.
Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.


The chapter "DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials" is available open access under a CC BY 4.0 License via link.springer.com.

• DNA nanotechnology
• Nucleic acids
• Self assembly
• Bionanomaterials
• Biotechnology

• School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China

  Chunhai Fan

• The Wallace H. Coulter Department of Biomedical Engineering, Emory University, Atlanta, USA

  Yonggang Ke

​Chunhai Fan is a K. C. Wong Chair Professor at Shanghai Jiao Tong University (SJTU). Before joining SJTU, he was a CAS Distinguished Professor at the Shanghai Institute of Applied Physics, Chinese Academy of Sciences. He published over 400 papers in peer-reviewed journals. He is a fellow of Royal Society of Chemistry (FRSC), an elected fellow of the International Society of Electrochemistry (ISE) and American Association for the Advancement of Science (AAAS). His research interests include DNA nanotechnology, biosensing and bioimaging.
Yonggang Ke is an assistant professor at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. He received his Ph.D. degree in chemistry from Arizona State University in 2009. He then worked as a postdoctoral fellow in the Department of Cancer Biology at Harvard University from 2009 to 2014. Dr. Ke is one of the leading experts in DNA nanotechnology. His current research focuses on programmable self-assembly of complex nanostructures and dynamic nanomachines using DNA and other biomolecules, functional nanomaterial self-assembly, drug delivery, and single-molecule biophysics.

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