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  • © 2020

Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications

  • Discusses the importance of systemic delivery technologies to anti-aging medicine
  • Provides comprehensive information about recent advances in the development and application of systemic delivery technologies
  • Contains glossary sections making the content of each chapter more accessible to readers
  • Highlights important concepts in the field after each chapter helping readers quickly retrieve key information about the text
  • Presents unsolved research questions after each chapter putting forward perspectives for future works to be conducted

Part of the book series: Healthy Ageing and Longevity (HAL, volume 13)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvi
  2. Fundamentals and Experimental Techniques in Systemic Delivery

    1. Front Matter

      Pages 1-1
    2. Current Status of Systemic Drug Delivery Research: A Bibliometric Study

      • Saba Ale Ebrahim, Maysam Zamani Pedram, Nader Ale Ebrahim
      Pages 39-55
    3. In Vivo Assessment of the Efficiency of Systemic Delivery

      • V. K. Ameena Shirin, Renu Sankar, Sabna Kotta, Kannissery Pramod
      Pages 87-120
  3. Systemic Delivery Techniques Based on Prodrug Design and Synthetic Materials

    1. Front Matter

      Pages 121-121
    2. Prodrug Design to Enhance Bioavailability and Systemic Delivery

      • Bruna Machado Araújo Sanches, Elizabeth Igne Ferreira
      Pages 123-154
    3. Use of Nanoparticulate Systems for Tackling Neurological Aging

      • Previn Ramiah, Pierre P. D. Kondiah, Yahya E. Choonara, Lisa C. du Toit, Viness Pillay
      Pages 187-218
  4. Systemic Delivery Techniques Based on Biological Materials

    1. Front Matter

      Pages 219-219
    2. Lipid-Based Nano-delivery of Phytobioactive Compounds in Anti-aging Medicine

      • Oleh Lushchak, Roman Karpenko, Alina Zayahckivska, Alexander Koliada, Alexander Vaiserman
      Pages 221-245
    3. Albumin-Based Carriers for Systemic Delivery to Tackle Cancer

      • Hossein Rahimi, Marziyeh Salehiabar, Soodabeh Davaran, Hossein Danafar, Hamed Nosrati
      Pages 247-270
    4. Exosomes as Vehicles for Systemic Drug Delivery

      • Magnolia Muk-Lan Lee, Wing-Yan Wong, Brandon Dow Chan, William Chi-Shing Tai
      Pages 271-296
  5. Systemic Delivery Techniques Based on Physical Means

    1. Front Matter

      Pages 297-297
    2. Use of Physical Approaches for Systemic Drug Delivery

      • Rajesh Vadlapatla, Zhijun Wang, Priyank Kumar, Nina Pavuluri
      Pages 299-325
    3. Inhalation as a Means of Systemic Drug Delivery

      • Tomasz R. Sosnowski
      Pages 327-344
  6. Modification of Carrier Properties for Systemic Delivery

    1. Front Matter

      Pages 345-345

About this book

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each.

The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will berequired for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases.

Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Editors and Affiliations

  • School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China

    Wing-Fu Lai

About the editor

Dr. Wing-Fu Lai obtained his M.Sc. in Materials Engineering and Nanotechnology from the City University of Hong Kong and his Ph.D. in Chemistry from the University of Hong Kong. He joined the Faculty in the School of Life and Health Sciences at the Chinese University of Hong Kong (Shenzhen) in 2019 and is also an Adjunct Faculty in the Department of Applied Biology and Chemical Technology at the Hong Kong Polytechnic University. His research interests cover the synthesis and engineering of polymeric materials for gene delivery and controlled drug release, and the development of nanoparticulate systems for theranostic applications. 

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access