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Trauma Induced Coagulopathy

  • Book
  • © 2021

Overview

Editors:
  1. Hunter B. Moore

    1. Department of Surgery, University of Colorado, Aurora, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Matthew D. Neal

    1. Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Ernest E. Moore

    1. Department of Surgery, University of Colorado Denver, Ernest E Moore Shock TraumaCenter at Denver Health, Denver, USA

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  • Outlines the current concepts that define trauma induced coagulopathy

  • Written by experts in the field

  • Provide therapeutic strategies to treat specific coagulation abnormalities following severe injury

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Table of contents (46 chapters)

  1. Front Matter

    Pages i-xix
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Historical Perspective of Trauma-Induced Coagulopathy

      • Ernest E. Moore, Hunter B. Moore
      Pages 3-11

    3. Epidemiology of Hemorrhage-Related Mortality

      • Angela Sauaia, Ernest E. Moore, Charles E. Wade, John B. Holcomb
      Pages 13-27

  3. Physiology of Hemostasis

    1. Front Matter

      Pages 29-29
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    2. Cell-Mediated Hemostasis

      • Maureane Hoffman
      Pages 31-41

    3. Thrombin-Antithrombin System

      • Toshiaki Iba
      Pages 43-51

    4. Physiology of Haemostasis: Plasmin-Antiplasmin System

      • Nicola J. Mutch, Claire S. Whyte
      Pages 53-74

  4. Pathophysiology of Trauma Induced Coagulopathy

    1. Front Matter

      Pages 75-75
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    2. Thrombin Formation

      • Beth A. Bouchard, Kalev Freeman
      Pages 77-84

    3. Platelets

      • Zachary A. Matthay, Lucy Zumwinkle Kornblith
      Pages 85-99

    4. Fibrinogen

      • Nathan J. White, Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore
      Pages 101-116

    5. Defining and Assessing the Endotheliopathy of Trauma and Its Implications on Trauma-Induced Coagulopathy and Trauma-Related Outcomes

      • Alison Baker Nair, Martin A. Schreiber, Shibani Pati
      Pages 117-133

    6. Protein C

      • Joshua J. Sumislawski, Benjamin M. Howard, Mitchell Jay Cohen
      Pages 135-156

    7. Fibrinolysis Dysregulation Following Trauma

      • Hunter B. Moore, Ernest E. Moore
      Pages 157-174

    8. Complement System

      • Narcis I. Popescu, Florea Lupu
      Pages 175-197

    9. Neutrophils, Inflammation, and Innate Immunity in Trauma-Induced Coagulopathy

      • Christopher D. Barrett, Michael B. Yaffe
      Pages 199-216

    10. Disseminated Intravascular Coagulation

      • Satoshi Gando, Takeshi Wada
      Pages 217-242

  5. Coagulation Assessment

    1. Front Matter

      Pages 243-243
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    2. Grading Clinical Coagulopathy and Predicting Massive Transfusion

      • Sophie Thorn, Marc Maegele
      Pages 245-263
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Keywords

About this book

The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy.  The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities.


Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.



Editors and Affiliations

  • Department of Surgery, University of Colorado, Aurora, USA

    Hunter B. Moore

  • Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA

    Matthew D. Neal

  • Department of Surgery, University of Colorado Denver, Ernest E Moore Shock TraumaCenter at Denver Health, Denver, USA

    Ernest E. Moore

About the editors

Hunter B. Moore
Transplant Surgery Fellow
Department of Surgery
University of Colorado
Aurora, CO
USA


Ernest E. Moore
Department of Surgery
University of Colorado Denver 
Ernest E Moore Shock Trauma Center at Denver Health
Denver, CO
USA


Matthew D. Neal
Department of Surgery
University of Pittsburgh Medical Center
Pittsburgh, PA
USA




Bibliographic Information

  • Book Title: Trauma Induced Coagulopathy

  • Editors: Hunter B. Moore, Matthew D. Neal, Ernest E. Moore

  • DOI: https://doi.org/10.1007/978-3-030-53606-0

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-53605-3Published: 13 October 2020

  • Softcover ISBN: 978-3-030-53608-4Published: 14 October 2021

  • eBook ISBN: 978-3-030-53606-0Published: 12 October 2020

  • Edition Number: 2

  • Number of Pages: XIX, 802

  • Number of Illustrations: 33 b/w illustrations

  • Topics: Traumatic Surgery, Intensive / Critical Care Medicine, General Surgery, Anesthesiology

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