Trauma Induced Coagulopathy

1. Front Matter

   Pages i-xix

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Historical Perspective of Trauma-Induced Coagulopathy

      • Ernest E. Moore, Hunter B. Moore

      Pages 3-11

   3. Epidemiology of Hemorrhage-Related Mortality

      • Angela Sauaia, Ernest E. Moore, Charles E. Wade, John B. Holcomb

      Pages 13-27

3. Physiology of Hemostasis

   1. Front Matter

      Pages 29-29

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   2. Cell-Mediated Hemostasis

      • Maureane Hoffman

      Pages 31-41

   3. Thrombin-Antithrombin System

      • Toshiaki Iba

      Pages 43-51

   4. Physiology of Haemostasis: Plasmin-Antiplasmin System

      • Nicola J. Mutch, Claire S. Whyte

      Pages 53-74

4. Pathophysiology of Trauma Induced Coagulopathy

   1. Front Matter

      Pages 75-75

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   2. Thrombin Formation

      • Beth A. Bouchard, Kalev Freeman

      Pages 77-84

   3. Platelets

      • Zachary A. Matthay, Lucy Zumwinkle Kornblith

      Pages 85-99

   4. Fibrinogen

      • Nathan J. White, Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore

      Pages 101-116

   5. Defining and Assessing the Endotheliopathy of Trauma and Its Implications on Trauma-Induced Coagulopathy and Trauma-Related Outcomes

      • Alison Baker Nair, Martin A. Schreiber, Shibani Pati

      Pages 117-133

   6. Protein C

      • Joshua J. Sumislawski, Benjamin M. Howard, Mitchell Jay Cohen

      Pages 135-156

   7. Fibrinolysis Dysregulation Following Trauma

      • Hunter B. Moore, Ernest E. Moore

      Pages 157-174

   8. Complement System

      • Narcis I. Popescu, Florea Lupu

      Pages 175-197

   9. Neutrophils, Inflammation, and Innate Immunity in Trauma-Induced Coagulopathy

      • Christopher D. Barrett, Michael B. Yaffe

      Pages 199-216

   10. Disseminated Intravascular Coagulation

       • Satoshi Gando, Takeshi Wada

       Pages 217-242

5. Coagulation Assessment

   1. Front Matter

      Pages 243-243

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   2. Grading Clinical Coagulopathy and Predicting Massive Transfusion

      • Sophie Thorn, Marc Maegele

      Pages 245-263

The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy.  The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities.


Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.

• anti-fibrinolytics
• hemorrhage-related mortality
• hemostasis
• plasma transfusion
• hemorrhage-related mortality
• Trauma Surgery

• Department of Surgery, University of Colorado, Aurora, USA

  Hunter B. Moore

• Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA

  Matthew D. Neal

• Department of Surgery, University of Colorado Denver, Ernest E Moore Shock TraumaCenter at Denver Health, Denver, USA

  Ernest E. Moore

Hunter B. Moore
Transplant Surgery Fellow
Department of Surgery
University of Colorado
Aurora, CO
USA


Ernest E. Moore
Department of Surgery
University of Colorado Denver 
Ernest E Moore Shock Trauma Center at Denver Health
Denver, CO
USA


Matthew D. Neal
Department of Surgery
University of Pittsburgh Medical Center
Pittsburgh, PA
USA

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