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The M2 Macrophage

  • Book
  • © 2020

Overview

Authors:
  1. Tamás Röszer

    1. Institute of Neurobiology, Ulm University, Ulm, Germany

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  • Provides a comprehensive summary of M2 macrophage functions
  • Fills an important gap in the literature on leukocyte biology
  • Can be used as a textbook or reference guide

Part of the book series: Progress in Inflammation Research (PIR, volume 86)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  4. Correction to: Practical Approaches in M2 Macrophage Biology: Analysis, Pharmacology, and Didactical Interpretation of M2 Macrophage Functions

    • Tamás Röszer
    Pages C1-C1

  5. Correction to: The M2 Macrophage

    • Tamás Röszer
    Pages C3-C3
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Keywords

About this book

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

Authors and Affiliations

  • Institute of Neurobiology, Ulm University, Ulm, Germany

    Tamás Röszer

About the author

Tamás Röszer is a Research Group Leader and Lecturer (Privatdozent) at the Institute of Neurobiology, Ulm University, Germany. His chief research interests are the endocrine control of immunity and metabolism, and macrophage biology in the context of development and physiology. He is the author of several research articles in the field of immunometabolism, diabetes and comparative molecular endocrinology, and reference books in nitric oxide biology and pathophysiology.



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