Skip to main content
SpringerLink
Log in
Book cover

Translational Pancreatic Cancer Research

From Understanding of Mechanisms to Novel Clinical Trials

  • Book
  • © 2020

Overview

Editors:
  1. Christoph W. Michalski

    1. Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Halle (Saale), Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Jonas Rosendahl

    1. Department of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Patrick Michl

    1. Department of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  4. Jörg Kleeff

    1. Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Halle (Saale), Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Presents how research results can be translated into clinical trials.
  • Incorporates a multi-disciplinary approach.
  • Written by experts in the field.

Part of the book series: Molecular and Translational Medicine (MOLEMED)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. PDAC Variants and Risk of Disease

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Subtypes of Pancreatic Adenocarcinoma

      • Luisa Ingenhoff, Lena Häberle, Irene Esposito
      Pages 3-16

  3. PDAC Precursors and Early Diagnosis

    1. Front Matter

      Pages 17-17
      Download chapter PDF

    2. Surveillance and Intervention in IPMN

      • A. Balduzzi, N. C. M. van Huijgevoort, G. Marchegiani, M. Engelbrecht, J. Stoker, J. Verheij et al.
      Pages 19-36

    3. Novel Biomarkers of Invasive IPMN

      • Stephen Hasak, Koushik K. Das
      Pages 37-70

  4. Diagnosis, Biomarkers and Stratification

    1. Front Matter

      Pages 71-71
      Download chapter PDF

    2. Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers

      • Lucy Oldfield, Lawrence Barrera, Dylan Williams, Anthony E. Evans, John Neoptolemos, Eithne Costello
      Pages 73-82

    3. Metabolic Biomarkers of Pancreatic Cancer

      • Ujjwal Mukund Mahajan, Qi Li, Beate Kamlage, Markus M. Lerch, Julia Mayerle
      Pages 83-96

    4. Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Druggable Biomarkers for Pancreatic Ductal Adenocarcinoma

      • Bo Kong, Helmut Friess
      Pages 97-106

    5. Circulating Tumor DNA as a Novel Biomarker for Pancreatic Cancer

      • Andreas W. Berger, Alexander Kleger
      Pages 107-116

    6. PDAC Subtypes/Stratification

      • Holly Brunton, Giuseppina Caligiuri, Gareth J. Inman, Peter Bailey
      Pages 117-128

    7. Circulating Tumor Cells as Biomarkers in Pancreatic Cancer

      • Alina Hasanain, Christopher L. Wolfgang
      Pages 129-143

  5. Personalized Treatment Approaches

    1. Front Matter

      Pages 145-145
      Download chapter PDF

    2. Personalized Models of Human PDAC

      • Hanna Heikenwälder, Susanne Roth
      Pages 147-156

    3. Therapeutic Targeting of Stromal Components

      • Albrecht Neesse
      Pages 157-168

    4. Epigenetic Targeting

      • Svenja Pichlmeier, Ivonne Regel
      Pages 169-182

    5. Targeting Metabolism

      • Yoshiaki Sunami
      Pages 183-202

    6. Targeting the Immune System in Pancreatic Cancer

      • D. Kabacaoglu, D. A. Ruess, Hana Algül
      Pages 203-218

    7. Phase I Trials in Pancreatic Cancer

      • Thomas Seufferlein, Angelika Kestler, Alica Beutel, Lukas Perkhofer, Thomas Ettrich
      Pages 219-232
Back to top

Keywords

About this book

​This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such asthose that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. 


Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

Editors and Affiliations

  • Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Halle (Saale), Germany

    Christoph W. Michalski, Jörg Kleeff

  • Department of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Germany

    Jonas Rosendahl, Patrick Michl

About the editors

Christoph W. Michalski
Department of Visceral, Vascular und Endocrine Surgery
University Hospital Halle (Saale)
Halle (Saale), Germany


Jonas Rosendahl
Department of Internal Medicine I
University Hospital Halle (Saale)
Halle (Saale), Germany


Patrick Michl
Department of Internal Medicine I
University Hospital Halle (Saale)
Halle (Saale), Germany


Jörg Kleeff
Department of Visceral, Vascular und Endocrine Surgery
University Hospital Halle (Saale)
Halle (Saale), Germany


Bibliographic Information

  • Book Title: Translational Pancreatic Cancer Research

  • Book Subtitle: From Understanding of Mechanisms to Novel Clinical Trials

  • Editors: Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff

  • Series Title: Molecular and Translational Medicine

  • DOI: https://doi.org/10.1007/978-3-030-49476-6

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-49475-9Published: 01 August 2020

  • Softcover ISBN: 978-3-030-49478-0Published: 02 August 2021

  • eBook ISBN: 978-3-030-49476-6Published: 31 July 2020

  • Series ISSN: 2197-7852

  • Series E-ISSN: 2197-7860

  • Edition Number: 1

  • Number of Pages: XII, 245

  • Number of Illustrations: 1 b/w illustrations, 17 illustrations in colour

  • Topics: Oncology, Pathology

Publish with us

Policies and ethics

Back to top

Search

Navigation