Overview
This book provides a brief review of drug development efforts and FDA approved kinase inhibitors
This book sets the stage and highlights the importance of kinase signaling pathways in physiological processes
This book identifies the genetic mutations that lead to kinase dysregulation and how this promotes the growth and survival of cancer cells
The book discusses the emergence of resistance to kinase inhibitors
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (8 chapters)
Keywords
About this book
Editors and Affiliations
About the editor
Paul Shapiro has a long-standing interest in protein kinases and their role in regulating cellular functions during disease. Specific areas focus on the discovery and development of function-selective mitogen-activated protein (MAP) kinase inhibitors with the goal of mitigating cancer cell proliferation and inflammation-induced lung injury associated with respiratory diseases. He received a Bachelor of Science degree from the University of Wisconsin-Madison and his doctorate in molecular physiology and biophysics from the University of Vermont. Dr. Shapiro completed post-doctoral training in the Department of Chemistry and Biochemistry at the University of Colorado-Boulder and is currently a professor of Pharmaceutical Sciences at the University of Maryland School of Pharmacy.
Bibliographic Information
Book Title: Next Generation Kinase Inhibitors
Book Subtitle: Moving Beyond the ATP Binding/Catalytic Sites
Editors: Paul Shapiro
DOI: https://doi.org/10.1007/978-3-030-48283-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-48282-4Published: 15 July 2020
Softcover ISBN: 978-3-030-48285-5Published: 15 July 2021
eBook ISBN: 978-3-030-48283-1Published: 14 July 2020
Edition Number: 1
Number of Pages: XII, 217
Number of Illustrations: 3 b/w illustrations, 56 illustrations in colour
Topics: Cancer Research