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Biochemistry of Cardiovascular Dysfunction in Obesity

  • Book
  • © 2020

Overview

Editors:
  1. Paramjit S. Tappia

    1. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Canada

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  2. Sukhwinder K. Bhullar

    1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, Canada

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  3. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, Canada

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  • Focuses on the biochemistry of obesity-induced cardiovascular dysfunction
  • Prevent the epidemic of obesity associated cardiovascular abnormalities
  • Covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 20)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
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  2. Pathophysiology of Cardiovascular Complications in Obesity

    1. Front Matter

      Pages 1-1
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    2. Different Faces of Obesity in Cardiovascular Diseases: Culprit or Protector

      • Negar Salehi, Aisha Siraj, Mojdeh Nasiri, Jawahar L. Mehta
      Pages 3-13

    3. Obesity-Induced Cardiovascular Complications and Therapeutic Intervention

      • Md. Jahangir Alam, Sanjay K. Banerjee
      Pages 15-53

    4. Maternal Obesity: Impacts on the Cardiovascular Health of Mother and Offspring

      • Fahmida Jahan, Ashim K. Bagchi, Rushita A. Bagchi
      Pages 55-75

    5. Role of Liver X Receptor in Cardiovascular Diseases

      • Tamhida Masi, Ramesh K. Goyal, Bhoomika M. Patel
      Pages 77-96

    6. Role of NLRP3 Inflammasomes in Obesity-Induced Cardiovascular Diseases

      • Krishna M. Boini, Pin-Lan Li, Saisudha Koka
      Pages 97-109

    7. Vicious Link of Obesity with Cardiometabolic and Renal Diseases

      • Amrit Pal Singh, Tajpreet Kaur, Harpal Singh Buttar
      Pages 111-124

    8. Role of Sodium-Glucose Co-transporters on Cardiac Function in Metabolic Syndrome Mammalians

      • Belma Turan
      Pages 125-144

    9. The Roles of HIFs in the Complications of Diabetes

      • Nuray Yazihan, Mehtap Kacar
      Pages 145-160

    10. Cellular and Molecular Mechanisms Contributing to Cardiac Hypertrophy in Obesity and Obesity-Related Hypertension

      • Norma L. Gómez-Viquez, Patrick Mailloux-Salinas, Tzindilú Molina-Muñoz, Rodrigo Guevara, Guadalupe Bravo, Karla Carvajal
      Pages 161-172

    11. Role of Epicardial Adipose Tissue in Heart Failure: From Basic to Clinical Perspectives

      • Hao Zhang, Mahmoud Gheblawi, Jiu-Chang Zhong, Gavin Y. Oudit
      Pages 173-194

    12. Epicardial Adipose Tissue in the Progression and Calcification of the Coronary Artery Disease

      • María Luna-Luna, Alejandro Zentella-Dehesa, Óscar Pérez-Méndez
      Pages 195-213

  3. Modification of Cardiovascular Complications in Obesity

    1. Front Matter

      Pages 215-215
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    2. Obesity and Coronary Artery Disease: Evaluation and Treatment

      • Marie-Eve Piché, Marie-Philippe Morin, Paul Poirier
      Pages 217-233

    3. Inflammation and Epicardial Adipose Tissue in the Pathobiology of Atherogenesis and Neointimal Hyperplasia Following Coronary Intervention

      • Finosh G. Thankam, Mohamed M. Radwan, Devendra K. Agrawal
      Pages 235-266

    4. Therapeutic Interventions of Endocannabinoid Signaling in Obesity-Related Cardiovascular Dysfunction

      • Vivek S. Kumawat, Siddhi Bagwe-Parab, Meena Chintamaneni, Ginpreet Kaur
      Pages 267-281

    5. Obesity and Cardiovascular Disease: Impact of Resveratrol as a Therapeutic

      • Xavier Lieben Louis, Sampath Krishnan, Jeffrey T. Wigle, Thomas Netticadan
      Pages 283-305

    6. Role of Flavonoids in Obesity Induced Cardiovascular Dysfunction

      • Zoha Ahmed, Antara Pal, Siddhi Bagwe-Parab, Ginpreet Kaur, Harpal Singh Buttar, Hardeep Singh Tuli
      Pages 307-327

    7. Homocysteine and Related B Vitamins in Pre-diabetes and Diabetes Mellitus

      • Slavica S. Mutavdzin, Dragan M. Djuric
      Pages 329-351
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Keywords

About this book

Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters).  
 
Theintent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system.


In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.

Editors and Affiliations

  • Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Canada

    Paramjit S. Tappia

  • Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, Canada

    Sukhwinder K. Bhullar, Naranjan S. Dhalla

Bibliographic Information

  • Book Title: Biochemistry of Cardiovascular Dysfunction in Obesity

  • Editors: Paramjit S. Tappia, Sukhwinder K. Bhullar, Naranjan S. Dhalla

  • Series Title: Advances in Biochemistry in Health and Disease

  • DOI: https://doi.org/10.1007/978-3-030-47336-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-47335-8Published: 04 October 2020

  • Softcover ISBN: 978-3-030-47338-9Published: 04 October 2021

  • eBook ISBN: 978-3-030-47336-5Published: 03 October 2020

  • Series ISSN: 2512-2142

  • Series E-ISSN: 2512-2150

  • Edition Number: 1

  • Number of Pages: XV, 401

  • Number of Illustrations: 7 b/w illustrations, 48 illustrations in colour

  • Topics: Human Physiology

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