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Tumor Microenvironment

Signaling Pathways – Part B

  • Book
  • © 2021

Overview

Editors:
  1. Alexander Birbrair

    1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

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  • Provides a comprehensive overview of the state-of-the-art research on how the tumor microenvironment exploits signaling pathways to fuel cancer progression
  • Describes several different signaling pathways in the tumor microenvironment, including Src, Neuregulin, Adenosine, TGFß, Androgen, Wnt signaling, and more
  • Illustrates in copious detail how cells in the tumor microenvironment co-opt signaling pathways to regulate cancer cells proliferation, survival, and invasion of other tissues

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1270)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Neuregulin Signaling in the Tumor Microenvironment

    • Ruxue Jia, Hu Zhao, Shuiliang Wang
    Pages 1-29

  3. HGF/c-Met Signalling in the Tumor Microenvironment

    • Alberto Zambelli, Giuseppe Biamonti, Angela Amato
    Pages 31-44

  4. Eph/Ephrin Signaling in the Tumor Microenvironment

    • Katsuaki Ieguchi, Yoshiro Maru
    Pages 45-56

  5. SRC Signaling in Cancer and Tumor Microenvironment

    • Ayse Caner, Elif Asik, Bulent Ozpolat
    Pages 57-71

  6. Purinergic Signaling Within the Tumor Microenvironment

    • Dobrin Draganov, Peter P. Lee
    Pages 73-87

  7. TGFβ Signaling in the Tumor Microenvironment

    • Cassandra Ringuette Goulet, Frédéric Pouliot
    Pages 89-105

  8. Wnt Signaling in the Tumor Microenvironment

    • Yongsheng Ruan, Heather Ogana, Eunji Gang, Hye Na Kim, Yong-Mi Kim
    Pages 107-121

  9. Lysophospholipid Signalling and the Tumour Microenvironment

    • Wayne Ng, Andrew Morokoff
    Pages 123-144

  10. Adenosine Signaling in the Tumor Microenvironment

    • Luca Antonioli, Matteo Fornai, Carolina Pellegrini, Vanessa D’Antongiovanni, Roberta Turiello, Silvana Morello et al.
    Pages 145-167

  11. Androgen Signaling in the Tumor Microenvironment

    • Berna C. Özdemir
    Pages 169-183

  12. Back Matter

    Pages 185-191
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Keywords

About this book

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more.

Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Editors and Affiliations

  • Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Alexander Birbrair

About the editor

Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Editor-in-Chief of Current Tissue Microenvironment Reports, and associate editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Bibliographic Information

  • Book Title: Tumor Microenvironment

  • Book Subtitle: Signaling Pathways – Part B

  • Editors: Alexander Birbrair

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-47189-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-47188-0Published: 30 October 2020

  • Softcover ISBN: 978-3-030-47191-0Published: 30 October 2021

  • eBook ISBN: 978-3-030-47189-7Published: 29 October 2020

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 191

  • Number of Illustrations: 6 b/w illustrations, 25 illustrations in colour

  • Topics: Cancer Research, Biomechanics, Cell Biology

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