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Cardiovascular Calcification and Bone Mineralization

  • Book
  • © 2020

Overview

Editors:
  1. Elena Aikawa

    1. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Joshua D. Hutcheson

    1. Department of Biomedical Engineering, Florida International University, Miami, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses treatments in bone disorders and ongoing therapeutic efforts in cardiovascular calcification
  • Provides clinical strategies that may be applicable to many types of cardiovascular diseases
  • Examines the physiological and pathological processes of cardiovascular and ectopic calcification as well as bone mineralization
  • Aggregates knowledge from across disparate calcification disciplines

Part of the book series: Contemporary Cardiology (CONCARD)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Cardiovascular Calcification

    1. Front Matter

      Pages 1-1
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    2. The History of Cardiovascular Calcification

      • Joshua D. Hutcheson, Elena Aikawa
      Pages 3-11

    3. Basic Pathology of Arterial and Valvular Calcification in Humans

      • Atsushi Sakamoto, Yu Sato, Aloke V. Finn, Renu Virmani
      Pages 13-45

    4. Developmental Pathways and Aortic Valve Calcification

      • M. Victoria Gomez-Stallons, Keira Hassel, Katherine E. Yutzey
      Pages 47-71

    5. Differential Mechanisms of Arterial and Valvular Calcification

      • Maximillian A. Rogers, Elena Aikawa
      Pages 73-95

    6. Calcifying Extracellular Vesicles: Biology, Characterization, and Mineral Formation

      • Hooi Hooi Ng, Jessica E. Molina, Joshua D. Hutcheson
      Pages 97-116

    7. Role of Biomechanical Stress and Mechanosensitive miRNAs in Calcific Aortic Valve Disease

      • Nicolas Villa-Roel, Kitae Ryu, Hanjoong Jo
      Pages 117-135

    8. The Role of Chronic Kidney Disease in Ectopic Calcification

      • Joanne Laycock, Malgorzata Furmanik, Mengxi Sun, Leon J. Schurgers, Rukshana Shroff, Catherine M. Shanahan
      Pages 137-166

    9. The Role of Calcification in Peripheral Artery Disease

      • Tanner I. Kim, Raul J. Guzman
      Pages 167-181

    10. Bioprosthetic Heart Valve Calcification: Clinicopathologic Correlations, Mechanisms, and Prevention

      • Frederick J. Schoen, Robert J. Levy
      Pages 183-215

  3. Ectopic Calcification

    1. Front Matter

      Pages 217-217
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    2. Electron Microscopy for the Characterization of Soft Tissue Mineralization

      • Elena Tsolaki, Sergio Bertazzo
      Pages 219-234

    3. Cardiovascular Calcification in Hutchinson-Gilford Progeria and Correlation with Age-Related Degenerative Calcification

      • Richard N. Mitchell
      Pages 235-245

    4. Calcinosis in Scleroderma

      • Sonia Nasreen Ahmad, Elena Gostjeva, Jianfei Ma, Richard Stratton
      Pages 247-261

    5. Placental Calcification: Long-standing Questions and New Biomedical Research Directions

      • Ana Correia-Branco, Sampada Kallol, Nimish Adhikari, Carlo Donato Caiaffa, Nirmala Jayaraman, Olga Kashpur et al.
      Pages 263-296

    6. Heterotopic Ossification Following Traumatic Blast Injury

      • Thomas E. Robinson, Sophie C. Cox, Liam M. Grover
      Pages 297-315

  4. Bone Mineralization

    1. Front Matter

      Pages 317-317
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    2. The Paradoxical Relationship Between Skeletal and Cardiovascular Mineralization

      • Sidney Iriana, Yin Tintut, Linda L. Demer
      Pages 319-332

    3. Cellular Contributors to Bone Homeostasis

      • Martina Rauner, Katharina Jähn, Haniyeh Hemmatian, Juliane Colditz, Claudia Goettsch
      Pages 333-371
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Keywords

About this book

The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed.


Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

Editors and Affiliations

  • Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

    Elena Aikawa

  • Department of Biomedical Engineering, Florida International University, Miami, USA

    Joshua D. Hutcheson

About the editors

Elena Aikawa, MD, PhDDirector, Vascular Biology Program
Director, Heart Valve Translational Research Program (HVTRP)
Brigham and Women’s Hospital
Associate Professor of Medicine
Harvard Medical School
Boston, MA


Joshua D. Hutcheson, PhD
Assistant Professor
Biomolecular Sciences Institute
Department of Biomedical Engineering
Florida International University
Miami, FL

Bibliographic Information

  • Book Title: Cardiovascular Calcification and Bone Mineralization

  • Editors: Elena Aikawa, Joshua D. Hutcheson

  • Series Title: Contemporary Cardiology

  • DOI: https://doi.org/10.1007/978-3-030-46725-8

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-46724-1Published: 02 July 2020

  • Softcover ISBN: 978-3-030-46727-2Published: 02 July 2021

  • eBook ISBN: 978-3-030-46725-8Published: 01 July 2020

  • Series ISSN: 2196-8969

  • Series E-ISSN: 2196-8977

  • Edition Number: 1

  • Number of Pages: XXI, 563

  • Number of Illustrations: 6 b/w illustrations, 102 illustrations in colour

  • Topics: Cardiology, Pathology, Biomedical Engineering/Biotechnology

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