Fluorescent Imaging in Medicinal Chemistry

1. Front Matter

   Pages i-vii

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2. Fluorescence Molecular Imaging of Medicinal Chemistry in Cancer

   • Jie Tian, Yang Du, Chu Tang, Yu An

   Pages 1-31

3. Organic Fluorescent Probes for Diagnostics and Bio-Imaging

   • Xingyue Yang, Jonathan F. Lovell, Niren Murthy, Yumiao Zhang

   Pages 33-53

4. Inorganic Fluorescent Nanomaterials

   • Taeho Kim, Jesse V. Jokerst

   Pages 55-80

5. Advancements of Second Near-Infrared Biological Window Fluorophores: Mechanism, Synthesis, and Application In Vivo

   • Shuqing He, Zhen Cheng

   Pages 81-123

6. X-Ray Excited Fluorescent Materials for Medical Application

   • Don Vernekohl, Lei Xing

   Pages 125-148

7. Applications of Fluorescent Protein-Based Sensors in Bioimaging

   • Uday Kumar Sukumar, Arutselvan Natarajan, Tarik F. Massoud, Ramasamy Paulmurugan

   Pages 149-183

8. Fluorescent Probes for Diagnostics of β-Galactosidase: From Micro to Macro

   • Anyao Bi, Xinchen Jiang, Tang Gao, Shuqi Yang, Yi Liu, Xiaohui Liu et al.

   Pages 185-201

9. The Present and Future of Optical Imaging Technologies in the Clinic: Diagnosis and Therapy

   • Evan P. Stater, Magdalena Skubal, Ryo Tamura, Jan Grimm

   Pages 203-223

10. Back Matter

    Pages 225-228

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This book reviews the most recent developments of fluorescent imaging techniques for medicinal chemistry research and biomedical applications, including cell imaging, in vitro diagnosis and in vivo imaging.

Fluorescent imaging techniques play an important role in basic research, drug discovery and clinical translation. They have great impact to many fields including chemical biology, cell biology, medical imaging, cancer diagnosis and treatment, pharmaceutical science, among others, and they have facilitated our understanding of diseases and helped to develop many novel powerful tools for imaging and treatment of diseases.

This book will appeal to scientists from numerous fields such as chemistry, pharmaceutical science, biology, materials science, and medicine, and it will serve as a very useful and handy resource for readers with different levels of scientific knowledge, ranging from entry level to professional level.

• Fluorescent reporters for drug discovery
• Organic fluorescent nanomaterials
• Inorganic fluorescent nanomaterials
• Image analysis
• NIR-II imaging
• X-ray excited fluorescent materials
• in vivo imaging
• cell imaging
• in vitro diagnosis

• Stanford University, Stanford, USA

  Zhen Cheng

Dr. Zhen Cheng is Associate Professor of Radiology and a member of the Molecular Imaging Program at Stanford (MIPS), BioX program, Canary Center at Stanford for Cancer Early Detection, and Stanford Cancer Center. He currently leads the Cancer Molecular Imaging Chemistry Laboratory (CMICL) of the MIPS, where he is developing novel molecular probes, non-invasive imaging techniques and bionanotechnology for the early detection and treatment of cancer. Dr. Cheng earned his PhD in Chemistry from University of Missouri-Columbia in 2001 and completed his post-doc training at Harvard Medical School in 2003. Dr. Cheng has published over 200 peer-reviewed articles. He has served as a reviewer for several funding agencies including NIH, DOD, DOE, etc. and also as an active reviewer for over 100 research journals. 

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