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Atlas of Lymphoscintigraphy and Sentinel Node Mapping

A Pictorial Case-Based Approach

  • Presents a collection of significant teaching cases illustrating the clinical applications of lymphoscintigraphy
  • Equips readers to solve diagnostic cases encountered in everyday nuclear medicine practice
  • Includes useful take-home tips

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii
  2. Anatomy and Physiology of Lymphatic Circulation: Application to Lymphatic Mapping

    • Omgo E. Nieweg, Pieter J. Tanis, Stanley P. L. Leong
    Pages 1-6
  3. Pathophysiology of Lymphatic Circulation in Different Disease Conditions

    • Rossella Di Stefano, Giulia Dibello, Francesca Felice, Paola A. Erba
    Pages 7-20
  4. Methodological Aspects of Lymphatic Mapping: Radiopharmaceuticals, Multimodal Lymphatic Mapping Agents, Instrumentations

    • Francesco Bartoli, Giuseppina Bisogni, Sara Vitali, Angela G. Cataldi, Alberto Del Guerra, Giuliano Mariani et al.
    Pages 21-51
  5. Methodological Aspects of Lymphoscintigraphy: Bicompartmental Versus Monocompartmental Radiocolloid Administration

    • Martina Sollini, Francesco Bartoli, Andrea Marciano, Roberta Zanca, Giovanni D’Errico, Giuliano Mariani et al.
    Pages 53-78
  6. Lymphoscintigraphy for the Differential Diagnosis of Peripheral Edema and Intracavitary Lymph Effusion

    • Martina Sollini, Roberto Boni, Andrea Marciano, Roberta Zanca, Francesco Bartoli, Paola A. Erba
    Pages 79-142
  7. The Sentinel Lymph Node Concept

    • Omgo E. Nieweg
    Pages 143-149
  8. General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging

    • Federica Orsini, Federica Guidoccio, Sergi Vidal-Sicart, Renato A. Valdés Olmos, Giuliano Mariani
    Pages 151-169
  9. SPECT/CT Image Generation and Criteria for Sentinel Lymph Node Mapping

    • Renato A. Valdés Olmos, Sergi Vidal-Sicart
    Pages 171-183
  10. Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Lymph Node Biopsy in Breast Cancer

    • Lenka M. Pereira Arias-Bouda, Sergi Vidal-Sicart, Renato A. Valdés Olmos
    Pages 185-217
  11. Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Lymph Node Biopsy in Cutaneous Melanoma

    • Sergi Vidal-Sicart, Andrés Perissinotti, Daphne D. D. Rietbergen, Renato A. Valdés Olmos
    Pages 219-259
  12. Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Head and Neck Cancers

    • Renato A. Valdés Olmos, W. Martin C. Klop, Maarten L. Donswijk
    Pages 261-290
  13. Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Non-small Cell Lung Cancer

    • Giuseppe Boni, Franca M. A. Melfi, Giampiero Manca, Federico Davini, Giuliano Mariani
    Pages 291-298
  14. Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Cancers of the Male Reproductive System

    • Hielke Martijn de Vries, Joost M. Blok, Hans N. Veerman, Florian van Beurden, Henk G. van der Poel, Renato A. Valdés Olmos et al.
    Pages 331-356
  15. Back Matter

    Pages 373-378

About this book

The main goal of the second edition of this book is to update the content on the rapidly growing field of lymphoscintigraphy, a radionuclide-based imaging procedure that provides information on the functional status of the lymphatic system. Although the technique was originally introduced to identify the cause of peripheral edema (i.e., blockage of the venous or lymphatic circulation), more recent and widespread applications include radioguided biopsy of the sentinel lymph node in patients with solid cancers. This procedure is crucial for the adequate planning of oncologic surgery in a growing number of cancers, most notably breast cancer, cutaneous melanoma, head and neck cancers, penile cancer, and cervical cancer.

The book focuses on the latest advances in lymphoscintigraphy techniques, including both novel tracers recently approved for clinical use (especially in the field of sentinel lymph node mapping) and the expanding role of hybrid imaging with SPECT/CT – and in sentinel node detection using hybrid tracers (radiolabeled and fluorescent) for dual-signature guidance. Each chapter addresses the clinical application of lymphoscintigraphy in different anatomic areas or disease conditions. After an introductory section concerning the pathophysiology of the specific site/disease, the clinical relevance and impact of lymphoscintigraphy is demonstrated by a collection of richly illustrated teaching cases describing the lymphoscintigraphic patterns most commonly observed, as well as anatomic variants and technical pitfalls. Emphasis is placed on tomographic multimodality imaging.

The book gathers contributions by experts in nuclear oncology, who have revised their chapters by updating the didactic material and adding clinical cases. Regarding sentinel lymph node biopsy in particular, a major distinction of this text is the incorporation of the staging guidelines of the American Joint Committee on Cancer (8th edition) into the didactic material.

Reviews

“The book is of excellent scientific quality, being at the same time easy to understand even for less experienced readers. The editorial work is structured so that it can be read in depth or as a quick reference for the various operators in the sector and beyond … . qualities that place the book in a prominent position on the desks of practitioners, of residents and of all the clinicians interested in the subject.” (Marilena Sicignano and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 48, 2021)

Editors and Affiliations

  • Regional Center of Nuclear Medicine Department of Translational Research and Advanced Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Giuliano Mariani

  • Nuclear Medicine Department, Hospital Clinic Barcelona, Barcelona, Catalonia, Spain

    Sergi Vidal-Sicart

  • Department of Radiology Section of Nuclear Medicine and Interventional Molecular Imaging Laboratory, Leiden University Medical Center, Leiden, The Netherlands

    Renato A. Valdés Olmos

About the editors

From 2001 to 2014, Dr. Giuliano Mariani was a Full Professor of Nuclear Medicine and Director of the Postgraduate Specialty School in Nuclear Medicine at the University of Pisa, as well as Director of the Regional Center of Nuclear Medicine at the University Hospital of Pisa (Pisa, Italy). He had previously held similar appointments at the University and the University Hospital of Genoa (Genoa, Italy), as Associate Professor of Nuclear Medicine. His academic career began at the CNR Institute of Clinical Physiology and at the University of Pisa in 1968. He was also a Visiting Scientist and Expert Consultant at the National Cancer Institute of the National Institutes of Health (NCI, NIH), Bethesda, Maryland, USA (between 1974–1978), and Visiting Professor and Lecturer of Radiology at the Harvard Medical School, Boston, Massachusetts, USA (between 1986–1990).

Dr. Mariani’s interests span virtually all of the clinical applications of Nuclear Medicine, including both diagnostic and therapeutic applications, with an emphasis on the development of novel techniques for radionuclide-based diagnosis and therapy of different tumors. He has published over 320 articles in international peer-reviewed journals. In addition to serving on the Editorial Boards of the most prestigious international journals on nuclear medicine and diagnostic imaging in general, Dr. Mariani has edited or co-edited 20 books and authored or coauthored over 100 book chapters. In addition, he currently serves as an Expert Consultant to the International Atomic Energy Agency (IAEA, Vienna) for developing and implementing nuclear medicine training programs around the world.

Sergi Vidal-Sicart is a Senior Consultant and Research Coordinator at the Nuclear Medicine Department of the Hospital Clínic Barcelona (University Hospital) and Specialist Physician at the Nuclear Medicine Department of Parc de Salut Mar (University Hospital del Mar). He is involved in projects concerning radioguided intervention and sentinel node biopsy using both conventional tracers and hybrid approaches for simultaneous radioactivity/fluorescence detection and intraoperative navigation in several malignancies. He is a founding member of the International Sentinel Node Society and member of the editorial boards of the Spanish Journal of Nuclear Medicine & Molecular Imaging and BMC Cancer. He is Former President of the Task Group on Radioguided Surgery within the Spanish Society of Nuclear Medicine and Molecular Imaging. In addition, he has been a contributing expert to training initiatives organized by the International Atomic Energy Agency  (IAEA) and the European Association of Nuclear Medicine (EANM).

Renato Alfredo Valdés Olmos is a former Nuclear Medicine Consultant at the Netherlands Cancer Institute–Antoni van Leeuwenhoek (NKI-AVL). Currently, he is Clinical Researcher and Senior Consultant at the Interventional Molecular Imaging laboratory and Nuclear Medicine Section of the Department of Radiology of the Leiden University Medical Center (LUMC). He has been involved in projects concerning image guided intervention and sentinel node biopsy using hybrid approaches for radioactivity/fluorescence detection and intraoperative navigation in various malignancies as well as in molecular imaging and biopsy of breast cancer resulting in more than three-hundred PubMed indexed publications and numerous PhD theses. Former member of the editorial board of the European Journal Nuclear Medicine & Molecular Imaging, he is member of the editorial board of the Spanish Journal of Nuclear Medicine & Molecular Imaging and also editor-in-chief of the Dutch Journal of Nuclear Medicine. He is a founding member of the International Sentinel Node Society and currently member of its board. Following participation as expert in training initiatives organized by the International Atomic Energy Agency  (IAEA) and the European Association of Nuclear Medicine (EANM),he has been one of the initiators of the European network RADIOguide for training and research on radioguided intervention. Former training coordinator on nuclear oncology at the NKI-AVL, he has also been in charge of training for nuclear medicine residents at the LUMC. He is currently involved in the fused radiology/nuclear medicine resident training at the Onze Lieve Vrouwe Hospital, Amsterdam.

 

 


Bibliographic Information

  • Book Title: Atlas of Lymphoscintigraphy and Sentinel Node Mapping

  • Book Subtitle: A Pictorial Case-Based Approach

  • Editors: Giuliano Mariani, Sergi Vidal-Sicart, Renato A. Valdés Olmos

  • DOI: https://doi.org/10.1007/978-3-030-45296-4

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-45295-7Published: 30 July 2020

  • Softcover ISBN: 978-3-030-45298-8Published: 31 July 2021

  • eBook ISBN: 978-3-030-45296-4Published: 29 July 2020

  • Edition Number: 2

  • Number of Pages: XII, 378

  • Number of Illustrations: 57 b/w illustrations, 221 illustrations in colour

  • Topics: Nuclear Medicine, Oncology, Surgery, Angiology, Pathology

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access