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Nrf2 and its Modulation in Inflammation

  • Book
  • © 2020

Overview

Editors:
  1. Huai Deng

    1. Department of Biology, University of Minnesota Duluth, Duluth, USA

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  • Provides a comprehensive and up-to-date account of Nrf2 research
  • Brings together mechanistic understanding and phenotypical/clinical knowledge about Nrf2
  • Covers role of Nrf2 in the immune response during inflammation, inflammation-triggered carcinogenesis, neuroinflammation, atherosclerosis, metabolic diseases, and others

Part of the book series: Progress in Inflammation Research (PIR, volume 85)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
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  2. Molecular Mechanisms of Nrf2 in Inflammation: Interactions Between Nrf2 and Inflammatory Mediators

    • Rong Wang, Viviana I. Perez
    Pages 1-21

  3. Nrf2 in Immune Responses During Inflammation

    • Miriam S. Hohmann, Tiago H. Zaninelli, Larissa Staurengo-Ferrari, Marília F. Manchope, Stephanie Badaro-Garcia, Andressa de Freitas et al.
    Pages 23-49

  4. Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and Diseases

    • Jennifer Carlson, Lindsey Price, Huai Deng
    Pages 51-76

  5. Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation

    • Hiromi Yamazaki, Ken Itoh
    Pages 77-96

  6. The Role of Nrf2 in the Cardiovascular System and Atherosclerosis

    • Bryan J. Mathis, Taixing Cui
    Pages 97-127

  7. Nrf2 and Inflammation-Triggered Carcinogenesis

    • Sayanta Sarkar, Noyel Ghosh, Mousumi Kundu, Parames C. Sil
    Pages 129-152

  8. Role of Nrf2 in Oxidative and Inflammatory Processes in Obesity and Metabolic Diseases

    • Maria M. Bayliak, Oleksandra B. Abrat
    Pages 153-187

  9. Modulators of Nrf2 Activation During Inflammation

    • Nady Braidy
    Pages 189-205

  10. Correction to: Nrf2 and its Modulation in Inflammation

    • Huai Deng
    Pages C1-C1
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Keywords

About this book

Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation, respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.

   

Editors and Affiliations

  • Department of Biology, University of Minnesota Duluth, Duluth, USA

    Huai Deng

About the editor

Dr. Deng is an assistant professor in the department of biology at the University of Minnesota Duluth. He obtained a bachelor's degree at Wuhan University and a master's degree at the University of Chinese Academy of Sciences. He got a PhD degree at Iowa State University and completed postdoctoral training at the University of Michigan and Howard Hughes Medical Institute.

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