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Tumor Microenvironment

Extracellular Matrix Components – Part A

  • Book
  • © 2020

Overview

Editors:
  1. Alexander Birbrair

    1. Department of Radiology, Columbia University Medical Center, New York, USA

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  • Provides the latest research on both extracellular matrix and cancer biology topics
  • Covers the different roles keratan sulphate, hyaluronan, fibronectin, and matrix metalloproteinases have in the tumor microenvironment
  • Illustrates the influence perlecan has in the tumor microencironment

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1245)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xi
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  2. The Tumor Microenvironment: Focus on Extracellular Matrix

    • Nathia Nathaly Rigoglio, Ana Carolina Silveira Rabelo, Jessica Borghesi, Gustavo de Sá Schiavo Matias, Paula Fratini, Pedro Henrique Dias Moura Prazeres et al.
    Pages 1-38

  3. Keratan Sulphate in the Tumour Environment

    • Anthony J. Hayes, James Melrose
    Pages 39-66

  4. Hyaluronan in the Tumor Microenvironment

    • Fiorella Mercedes Spinelli, Daiana Lujan Vitale, Ina Sevic, Laura Alaniz
    Pages 67-83

  5. Fibronectin in the Tumor Microenvironment

    • Peter Qiao, Zheng-Rong Lu
    Pages 85-96

  6. Matrix Metalloproteinases’ Role in Tumor Microenvironment

    • Georgina Gonzalez-Avila, Bettina Sommer, A. Armando García-Hernández, Carlos Ramos
    Pages 97-131

  7. Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment

    • Lissette A. Cruz, Tristen V. Tellman, Mary C. Farach-Carson
    Pages 133-146

  8. Heparan Sulfate in the Tumor Microenvironment

    • Barbara Bartolini, Elena Caravà, Ilaria Caon, Arianna Parnigoni, Paola Moretto, Alberto Passi et al.
    Pages 147-161

  9. The Role of Glypican-1 in the Tumour Microenvironment

    • Maria E. Lund, Douglas H. Campbell, Bradley J. Walsh
    Pages 163-176

  10. Back Matter

    Pages 177-181
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Keywords

About this book

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more.
 
Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research.


All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Editors and Affiliations

  • Department of Radiology, Columbia University Medical Center, New York, USA

    Alexander Birbrair

About the editor

Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA).

Bibliographic Information

  • Book Title: Tumor Microenvironment

  • Book Subtitle: Extracellular Matrix Components – Part A

  • Editors: Alexander Birbrair

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-40146-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-40145-0Published: 08 April 2020

  • Softcover ISBN: 978-3-030-40148-1Published: 08 April 2021

  • eBook ISBN: 978-3-030-40146-7Published: 07 April 2020

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 181

  • Number of Illustrations: 5 b/w illustrations, 24 illustrations in colour

  • Topics: Cancer Research, Stem Cells, Regenerative Medicine/Tissue Engineering

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