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Myocarditis

Pathogenesis, Diagnosis and Treatment

  • Book
  • © 2020

Overview

Editors:
  1. Alida L. P. Caforio

    1. Cardiology, Department of Cardiac Thoracic Vascular Science and Public Health, University of Padova, Policlinico Universitario, Padova, Italy

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  • Illustrates diagnostic work-up and etiology-based therapy

  • Highlights the autoimmune origin of myocarditis

  • Written by leading international experts in the field

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Classification, Histopathology, Immunohistology, and Molecular Diagnosis of Myocarditis

    • Stefania Rizzo, Elisa Carturan, Gaetano Thiene, Cristina Basso
    Pages 1-17

  3. Clinical Presentation of Myocarditis

    • Alida L. P. Caforio, Renzo Marcolongo, Chun-Yan Cheng, Anna Baritussio, Giuseppe Tarantini, Sabino Iliceto
    Pages 19-36

  4. Endomyocardial Biopsy

    • Cristina Chimenti, Andrea Frustaci
    Pages 37-44

  5. Genetic Basis of Myocarditis: Myth or Reality?

    • Eloisa Arbustini, Nupoor Narula, Lorenzo Giuliani, Alessandro Di Toro
    Pages 45-89

  6. Viral Myocarditis: From Experimental Models to Diagnosis in Patients

    • Sabine Pankuweit, Karin Klingel
    Pages 91-109

  7. Autoimmune Myocarditis: Animal Models

    • Valeria Poli, Katelyn A. Bruno, DeLisa Fairweather
    Pages 111-127

  8. Electrocardiography

    • Claudio Rapezzi, Alberto Foà, Raffaello Ditaranto
    Pages 129-142

  9. Standard and Advanced Echocardiography

    • Silvia Gianstefani, Anna Baritussio, Chun-Yan Cheng, Luigi P. Badano, Alida L. P. Caforio, Sabino Iliceto
    Pages 143-161

  10. Cardiac Magnetic Resonance Imaging in Myocarditis

    • Martina Perazzolo Marra, Alberto Cipriani
    Pages 163-171

  11. Organ-Specific Autoimmune Myocarditis

    • Alida L. P. Caforio, Chun-Yan Cheng, Mara Seguso, Nicoletta Gallo, Renzo Marcolongo, Sabino Iliceto
    Pages 173-194

  12. Myocarditis in Systemic Immune-Mediated Diseases

    • Alida L. P. Caforio, Renzo Marcolongo, Anna Baritussio, Loira Leoni, Chun-Yan Cheng, Sabino Iliceto
    Pages 195-221

  13. Giant Cell and Hypersensitivity Myocarditis

    • Yahaira Ortiz Gonzalez, Leslie T. Cooper
    Pages 223-241

  14. Myocarditis in Children

    • Giuseppe Limongelli, Daniele Masarone, Emanuele Monda, Augusto Esposito, Marta Rubino, Giuseppe Pacileo
    Pages 243-260

  15. Immunosuppressive Therapy in Myocarditis: Lessons from Clinical Trials and Future Perspectives

    • Andrea Frustaci, Cristina Chimenti
    Pages 261-267

  16. Immunomodulation and Immunoadsorption in Inflammatory Dilated Cardiomyopathy

    • Bishwas Chamling, Stephanie Könemann, Marcus Dörr, Stephan B. Felix
    Pages 269-283

  17. Clinical Management and Follow-Up of Myocarditis Patients on Immunosuppressive Therapy

    • Renzo Marcolongo, Anna Baritussio, Silvia Gianstefani, Chun-Yan Cheng, Sabino Iliceto, Alida L. P. Caforio
    Pages 285-295

  18. Antiviral Therapies: A Critical Reappraisal

    • Ahmed Elsanhoury, Sophie Van Linthout, Carsten Tschöpe
    Pages 297-316

  19. Conventional Cardiological Therapies

    • Gianfranco Sinagra, Piero Gentile, Jessica Artico, Antonio Cannata’, Enrico Fabris, Merlo Marco
    Pages 317-328

  20. Arrhythmias in Myocarditis

    • Riccardo Vio, Alessandro Zorzi, Domenico Corrado
    Pages 329-341
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Keywords

About this book

This book is an up-to-date, comprehensive, clinically oriented guide to the diagnosis and treatment of patients with myocarditis. The opening chapters address the classification, histopathology and molecular diagnosis, as well as the polymorphic clinical presentations, ranging from myocardial infarction with normal coronary arteries; arrhythmias of variable type and clinical severity and fulminant, acute, sub-acute or chronic heart failure; to life-threatening unexplained cardiogenic shock and sudden cardiac death.


Including chapters from leading International experts in the field, it covers all key issues from bench to bedside. Topics presented include epidemiology, etiology, pathogenesis, clinical and diagnostic work-up, the role of endomyocardial biopsy and of non-invasive cardiac imaging, risk stratification, and cardiological and etiology-specific management and follow-up. For each topic, a comprehensive review of the current literature is provided and practical suggestions are offered for short- and long-term management. Lastly, future perspectives and gaps in the current knowledge are also addressed.

The book also covers a key discovery of last the 2 decades, namely the autoimmune origin of myocarditis in a sizable proportion of patients, discussing in detail the role of immunosuppression and immunomodulation, as well as the need for a multidisciplinary approach to the disease.

Mainly intended for cardiologists, general physicians, clinical immunologists and rheumatologists, it is also a valuable tool for residents in Cardiology, Internal Medicine, Clinical Immunology and Rheumatology.

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Editors and Affiliations

  • Cardiology, Department of Cardiac Thoracic Vascular Science and Public Health, University of Padova, Policlinico Universitario, Padova, Italy

    Alida L. P. Caforio

About the editor

Alida L. P. Caforio received her Medicine and Surgery degree and her specialty Cardiology diploma from the Pisa University and attended a pre-graduate and a post-graduate course at the Faculty of Medicine at Scuola Superiore S. Anna, Pisa. She was a clinical research fellow at the Cardiovascular Research Unit, Royal Postgraduate Medical School, Hammersmith Hospital and at the Department of Cardiological Sciences, St. George’s Hospital Medical School, London University, where she was subsequently appointed as honorary lecturer. She was involved in a joint clinical research project between this department (in collaboration with Prof. William J McKenna) and the Department of Immunology, Middlesex Hospital, University College Medical School, London (Prof. GF Bottazzo) on the role of autoimmunity in myocarditis and in dilated cardiomyopathy.  She has received numerous academic and research awards from national and international cardiac societies, including the Italian (SIC) and the European Society of Cardiology (ESC).  She was elected chairperson of both SIC and ESC Myocardial and Pericardial Disease Working Groups and was the coordinator of recent ESC expert consensus statements on myocarditis (2013, 2018) and dilated cardiomyopathy (2017). She is currently Chair of the ESC Long term Cardiomyopathy and Myocarditis Registry. Since 1997 she has been a senior staff cardiologist in the Division of Cardiology, Department of Cardiological, Thoracic and Vascular Sciences at the University of Padova-Azienda ospedaliera di Padova, and in 2018 was appointed associate professor of Cardiology at the University of Padova. Her main research focus relates to cardiac immunology, cardiomyopathies and transplantation, invasive and non-invasive cardiovascular imaging techniques particularly in the field of myocardial and pericardial disease.  Prof. Caforio is the author of 566 publications, 141 of which are peer-reviewed full papers, indexed in Medline.

Bibliographic Information

  • Book Title: Myocarditis

  • Book Subtitle: Pathogenesis, Diagnosis and Treatment

  • Editors: Alida L. P. Caforio

  • DOI: https://doi.org/10.1007/978-3-030-35276-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-35275-2Published: 07 March 2020

  • Softcover ISBN: 978-3-030-35278-3Published: 07 March 2021

  • eBook ISBN: 978-3-030-35276-9Published: 06 March 2020

  • Edition Number: 1

  • Number of Pages: X, 353

  • Number of Illustrations: 8 b/w illustrations, 46 illustrations in colour

  • Topics: Cardiology, Rheumatology, Immunology

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