Overview
- Offers a comprehensive overview of the research on pertussis infection and vaccination
- Discusses pertussis prevention, control and clinical management
- Highlights the latest vaccination strategies and novel vaccines
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1183)
Part of the book sub series: Advances in Microbiology, Infectious Diseases and Public Health (AMIDPH)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (11 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines.
Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replacedolder-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.
This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.
Editors and Affiliations
About the editors
Dr. Giorgio Fedele
Istituto Superiore di SanitÃ
Roma, Italy
Email : giorgio.fedele@iss.it
Dr. Clara Maria Ausiello
Roma, Italy
Email : clara.ausiello@gmail.com
Bibliographic Information
Book Title: Pertussis Infection and Vaccines
Book Subtitle: Advances in Microbiology, Infectious Diseases and Public Health Volume 12
Editors: Giorgio Fedele, Clara Maria Ausiello
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-33249-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-33248-8Published: 07 January 2020
Softcover ISBN: 978-3-030-33251-8Published: 08 January 2021
eBook ISBN: 978-3-030-33249-5Published: 06 January 2020
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 170
Number of Illustrations: 10 illustrations in colour
Topics: Medical Microbiology, Bacteriology, Infectious Diseases